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Disruption of the microbiota across multiple body sites in critically ill children

Overview of attention for article published in Microbiome, December 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

blogs
1 blog
twitter
28 tweeters
facebook
1 Facebook page
reddit
1 Redditor

Citations

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59 Dimensions

Readers on

mendeley
116 Mendeley
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Title
Disruption of the microbiota across multiple body sites in critically ill children
Published in
Microbiome, December 2016
DOI 10.1186/s40168-016-0211-0
Pubmed ID
Authors

Matthew B. Rogers, Brian Firek, Min Shi, Andrew Yeh, Rachel Brower-Sinning, Victoria Aveson, Brittany L. Kohl, Anthony Fabio, Joseph A. Carcillo, Michael J. Morowitz

Abstract

Despite intense interest in the links between the microbiome and human health, little has been written about dysbiosis among ICU patients. We characterized microbial diversity in samples from 37 children in a pediatric ICU (PICU). Standard measures of alpha and beta diversity were calculated, and results were compared with data from adult and pediatric reference datasets. Bacterial 16S rRNA gene sequences were analyzed from 71 total tongue swabs, 50 skin swabs, and 77 stool samples or rectal swabs. The mean age of the PICU patients was 2.9 years (range 1-9 years), and many were chronically ill children that had previously been hospitalized in the PICU. Relative to healthy adults and children, alpha diversity was decreased in PICU GI and tongue but not skin samples. Measures of beta diversity indicated differences in community membership at each body site between PICU, adult, and pediatric groups. Taxonomic alterations in the PICU included enrichment of gut pathogens such as Enterococcus and Staphylococcus at multiple body sites and depletion of commensals such as Faecalibacterium and Ruminococcus from GI samples. Alpha and beta diversity were unstable over time in patients followed longitudinally. We observed the frequent presence of "dominant" pathogens in PICU samples at relative abundance >50%. PICU samples were characterized by loss of site specificity, with individual taxa commonly present simultaneously at three sample sites on a single individual. Some pathogens identified by culture of tracheal aspirates were commonly observed in skin samples from the same patient. We conclude that the microbiota in critically ill children differs sharply from the microbiota of healthy children and adults. Acknowledgement of dysbiosis associated with critical illness could provide opportunities to modulate the microbiota with precision and thereby improve patient outcomes.

Twitter Demographics

The data shown below were collected from the profiles of 28 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 116 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 21%
Student > Ph. D. Student 15 13%
Student > Master 14 12%
Student > Bachelor 9 8%
Other 7 6%
Other 26 22%
Unknown 21 18%
Readers by discipline Count As %
Medicine and Dentistry 28 24%
Agricultural and Biological Sciences 15 13%
Immunology and Microbiology 15 13%
Biochemistry, Genetics and Molecular Biology 14 12%
Veterinary Science and Veterinary Medicine 4 3%
Other 13 11%
Unknown 27 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2020.
All research outputs
#1,158,638
of 20,114,180 outputs
Outputs from Microbiome
#417
of 1,206 outputs
Outputs of similar age
#31,678
of 411,020 outputs
Outputs of similar age from Microbiome
#27
of 62 outputs
Altmetric has tracked 20,114,180 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,206 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 411,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.