Identification of novel arthropod vector G protein-coupled receptors

Ronald J Nowling, Jenica L Abrudan, Douglas A Shoue, Badi’ Abdul-Wahid, Mariha Wadsworth, Gwen Stayback, Frank H Collins, Mary Ann McDowell, Jesús A Izaguirre

The control of vector-borne diseases, such as malaria, dengue fever, and typhus fever is often achieved with the use of insecticides. Unfortunately, insecticide resistance is becoming common among different vector species. There are currently no chemical alternatives to these insecticides because new human-safe classes of molecules have yet to be brought to the vector-control market. The identification of novel targets offer opportunities for rational design of new chemistries to control vector populations. One target family, G protein-coupled receptors (GPCRs), has remained relatively under explored in terms of insecticide development.