Title |
Gene regulation by the act of long non-coding RNA transcription
|
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Published in |
BMC Biology, May 2013
|
DOI | 10.1186/1741-7007-11-59 |
Pubmed ID | |
Authors |
Aleksandra E Kornienko, Philipp M Guenzl, Denise P Barlow, Florian M Pauler |
Abstract |
Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in the mouse and human transcriptomes. Two important questions are whether all lncRNAs are functional and how they could exert a function. Several lncRNAs have been shown to function through their product, but this is not the only possible mode of action. In this review we focus on a role for the process of lncRNA transcription, independent of the lncRNA product, in regulating protein-coding-gene activity in cis. We discuss examples where lncRNA transcription leads to gene silencing or activation, and describe strategies to determine if the lncRNA product or its transcription causes the regulatory effect. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 19% |
United Kingdom | 2 | 13% |
Chile | 1 | 6% |
Austria | 1 | 6% |
France | 1 | 6% |
Costa Rica | 1 | 6% |
Unknown | 7 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 8 | 50% |
Members of the public | 6 | 38% |
Science communicators (journalists, bloggers, editors) | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 1% |
United Kingdom | 7 | 1% |
Brazil | 4 | <1% |
Portugal | 2 | <1% |
France | 2 | <1% |
Denmark | 2 | <1% |
Netherlands | 2 | <1% |
Mexico | 2 | <1% |
Finland | 2 | <1% |
Other | 14 | 2% |
Unknown | 629 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 188 | 28% |
Researcher | 115 | 17% |
Student > Master | 85 | 13% |
Student > Bachelor | 74 | 11% |
Student > Doctoral Student | 33 | 5% |
Other | 86 | 13% |
Unknown | 92 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 268 | 40% |
Biochemistry, Genetics and Molecular Biology | 210 | 31% |
Medicine and Dentistry | 32 | 5% |
Computer Science | 14 | 2% |
Immunology and Microbiology | 11 | 2% |
Other | 38 | 6% |
Unknown | 100 | 15% |