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Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells

Overview of attention for article published in BMC Neuroscience, January 2017
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Title
Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells
Published in
BMC Neuroscience, January 2017
DOI 10.1186/s12868-016-0320-5
Pubmed ID
Authors

Hung-Te Hsu, Yi-Ching Lo, Yan-Ming Huang, Yu-Ting Tseng, Sheng-Nan Wu

Abstract

Sugammadex (SGX) is a modified γ-cyclodextrin used for reversal of steroidal neuromuscular blocking agents during general anesthesia. Despite its application in clinical use, whether SGX treatment exerts any effects on membrane ion currents in neurons remains largely unclear. In this study, effects of SGX treatment on ion currents, particularly on delayed-rectifier K(+) current [I K(DR)], were extensively investigated in differentiated NSC-34 neuronal cells. After cells were exposed to SGX (30 μM), there was a reduction in the amplitude of I K(DR) followed by an apparent slowing in current activation in response to membrane depolarization. The challenge of cells with SGX produced a depolarized shift by 15 mV in the activation curve of I K(DR) accompanied by increased gating charge of this current. However, the inactivation curve of I K(DR) remained unchanged following SGX treatment, as compared with that in untreated cells. According to a minimal reaction scheme, the lengthening of activation time constant of I K(DR) caused by cell treatment with different SGX concentrations was quantitatively estimated with a dissociation constant of 17.5 μM, a value that is clinically achievable. Accumulative slowing in I K(DR) activation elicited by repetitive stimuli was enhanced in SGX-treated cells. SGX treatment did not alter the amplitude of voltage-gated Na(+) currents. In SGX-treated cells, dexamethasone (30 μM), a synthetic glucocorticoid, produced little or no effect on L-type Ca(2+) currents, although it effectively suppressed the amplitude of this current in untreated cells. The treatment of SGX may influence the amplitude and gating of I K(DR) and its actions could potentially contribute to functional activities of motor neurons if similar results were found in vivo.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 268 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 51 19%
Student > Master 50 19%
Student > Doctoral Student 23 9%
Researcher 18 7%
Lecturer 18 7%
Other 34 13%
Unknown 74 28%
Readers by discipline Count As %
Social Sciences 67 25%
Business, Management and Accounting 29 11%
Arts and Humanities 26 10%
Computer Science 11 4%
Psychology 10 4%
Other 50 19%
Unknown 75 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2017.
All research outputs
#20,376,559
of 22,925,760 outputs
Outputs from BMC Neuroscience
#1,057
of 1,248 outputs
Outputs of similar age
#355,981
of 421,214 outputs
Outputs of similar age from BMC Neuroscience
#17
of 36 outputs
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So far Altmetric has tracked 1,248 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.