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The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma

Overview of attention for article published in Acta Neuropathologica Communications, May 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

twitter
2 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
61 Mendeley
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Title
The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma
Published in
Acta Neuropathologica Communications, May 2013
DOI 10.1186/2051-5960-1-19
Pubmed ID
Authors

Kristian W Pajtler, Christina Weingarten, Theresa Thor, Annette Künkele, Lukas C Heukamp, Reinhard Büttner, Takayoshi Suzuki, Naoki Miyata, Michael Grotzer, Anja Rieb, Annika Sprüssel, Angelika Eggert, Alexander Schramm, Johannes H Schulte

Abstract

Medulloblastoma is a leading cause of childhood cancer-related deaths. Current aggressive treatments frequently lead to cognitive and neurological disabilities in survivors. Novel targeted therapies are required to improve outcome in high-risk medulloblastoma patients and quality of life of survivors. Targeting enzymes controlling epigenetic alterations is a promising approach recently bolstered by the identification of mutations in histone demethylating enzymes in medulloblastoma sequencing efforts. Hypomethylation of lysine 4 in histone 3 (H3K4) is also associated with a dismal prognosis for medulloblastoma patients. Functional characterization of important epigenetic key regulators is urgently needed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 21%
Researcher 9 15%
Student > Master 8 13%
Student > Bachelor 5 8%
Student > Doctoral Student 4 7%
Other 12 20%
Unknown 10 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 20%
Agricultural and Biological Sciences 11 18%
Medicine and Dentistry 10 16%
Chemistry 5 8%
Neuroscience 3 5%
Other 9 15%
Unknown 11 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2013.
All research outputs
#1,989,360
of 4,507,280 outputs
Outputs from Acta Neuropathologica Communications
#90
of 186 outputs
Outputs of similar age
#37,145
of 89,870 outputs
Outputs of similar age from Acta Neuropathologica Communications
#2
of 4 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 186 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,870 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.