Title |
GWIS - model-free, fast and exhaustive search for epistatic interactions in case-control GWAS
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Published in |
BMC Genomics, May 2013
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DOI | 10.1186/1471-2164-14-s3-s10 |
Pubmed ID | |
Authors |
Benjamin Goudey, David Rawlinson, Qiao Wang, Fan Shi, Herman Ferra, Richard M Campbell, Linda Stern, Michael T Inouye, Cheng Soon Ong, Adam Kowalczyk |
Abstract |
It has been hypothesized that multivariate analysis and systematic detection of epistatic interactions between explanatory genotyping variables may help resolve the problem of "missing heritability" currently observed in genome-wide association studies (GWAS). However, even the simplest bivariate analysis is still held back by significant statistical and computational challenges that are often addressed by reducing the set of analysed markers. Theoretically, it has been shown that combinations of loci may exist that show weak or no effects individually, but show significant (even complete) explanatory power over phenotype when combined. Reducing the set of analysed SNPs before bivariate analysis could easily omit such critical loci. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 3 | 3% |
United States | 3 | 3% |
Australia | 2 | 2% |
Switzerland | 1 | <1% |
South Africa | 1 | <1% |
United Kingdom | 1 | <1% |
Italy | 1 | <1% |
Spain | 1 | <1% |
Saudi Arabia | 1 | <1% |
Other | 2 | 2% |
Unknown | 86 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 32% |
Researcher | 22 | 22% |
Student > Master | 15 | 15% |
Professor | 6 | 6% |
Professor > Associate Professor | 6 | 6% |
Other | 15 | 15% |
Unknown | 5 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 35 | 34% |
Computer Science | 30 | 29% |
Biochemistry, Genetics and Molecular Biology | 12 | 12% |
Mathematics | 5 | 5% |
Engineering | 5 | 5% |
Other | 7 | 7% |
Unknown | 8 | 8% |