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Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG

Overview of attention for article published in Acta Neuropathologica Communications, May 2013
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  • Good Attention Score compared to outputs of the same age (71st percentile)

Mentioned by

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2 tweeters
patent
1 patent

Citations

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47 Dimensions

Readers on

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71 Mendeley

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Title
Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG
Published in
Acta Neuropathologica Communications, May 2013
DOI 10.1186/2051-5960-1-18
Pubmed ID
24252742
Authors

Anna C Navis, Simone P Niclou, Fred Fack, Daniel Stieber, Sanne van Lith, Kiek Verrijp, Alan Wright, Jonathan Stauber, Bastiaan Tops, Irene Otte-Holler, Ron A Wevers, Arno van Rooij, Stefan Pusch, Andreas von Deimling, Wikky Tigchelaar, Cornelis JF van Noorden, Pieter Wesseling, William PJ Leenders

Abstract

Point mutations in genes encoding NADP+-dependent isocitrate dehydrogenases (especially IDH1) are common in lower grade diffuse gliomas and secondary glioblastomas and occur early during tumor development. The contribution of these mutations to gliomagenesis is not completely understood and research is hampered by the lack of relevant tumor models. We previously described the development of the patient-derived high-grade oligodendroglioma xenograft model E478 that carries the commonly occurring IDH1-R132H mutation. We here report on the analyses of E478 xenografts at the genetic, histologic and metabolic level.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
United Kingdom 1 1%
Unknown 68 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 23%
Student > Ph. D. Student 15 21%
Student > Master 11 15%
Other 5 7%
Student > Postgraduate 4 6%
Other 13 18%
Unknown 7 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 30%
Medicine and Dentistry 18 25%
Agricultural and Biological Sciences 14 20%
Chemistry 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 5 7%
Unknown 8 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2018.
All research outputs
#5,109,600
of 17,364,317 outputs
Outputs from Acta Neuropathologica Communications
#696
of 1,061 outputs
Outputs of similar age
#46,467
of 164,351 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 17,364,317 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,061 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,351 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

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