Title |
msbB deletion confers acute sensitivity to CO2 in Salmonella enterica serovar Typhimurium that can be suppressed by a loss-of-function mutation in zwf
|
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Published in |
BMC Microbiology, August 2009
|
DOI | 10.1186/1471-2180-9-170 |
Pubmed ID | |
Authors |
Verena Karsten, Sean R Murray, Jeremy Pike, Kimberly Troy, Martina Ittensohn, Manvel Kondradzhyan, K Brooks Low, David Bermudes |
Abstract |
Pathogens tolerate stress conditions that include low pH, oxidative stress, high salt and high temperature in order to survive inside and outside their hosts. Lipopolysaccharide (LPS), which forms the outer-leaflet of the outer membrane in Gram-negative bacteria, acts as a permeability barrier. The lipid A moiety of LPS anchors it to the outer membrane bilayer. The MsbB enzyme myristoylates the lipid A precursor and loss of this enzyme, in Salmonella, is correlated with reduced virulence and severe growth defects that can both be compensated with extragenic suppressor mutations. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 11% |
Unknown | 17 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 32% |
Researcher | 3 | 16% |
Student > Master | 3 | 16% |
Student > Doctoral Student | 2 | 11% |
Student > Bachelor | 1 | 5% |
Other | 3 | 16% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 32% |
Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Engineering | 4 | 21% |
Immunology and Microbiology | 2 | 11% |
Chemistry | 1 | 5% |
Other | 1 | 5% |
Unknown | 1 | 5% |