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Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells

Overview of attention for article published in Epigenetics & Chromatin, June 2013
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Title
Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells
Published in
Epigenetics & Chromatin, June 2013
DOI 10.1186/1756-8935-6-15
Pubmed ID
Authors

Irina A Maksakova, Peter J Thompson, Preeti Goyal, Steven JM Jones, Prim B Singh, Mohammad M Karimi, Matthew C Lorincz

Abstract

In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and its binding partner KAP1/TRIM28. In contrast, the H3K9 KMTases G9a and GLP and HP1 proteins are dispensable for this process. Intriguingly, MERVL retroelements are actively transcribed exclusively in the two-cell (2C) embryo, but the molecular basis of silencing of these class III ERVs at later developmental stages has not been systematically addressed.

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X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 2 1%
France 1 <1%
Japan 1 <1%
Portugal 1 <1%
Unknown 185 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 53 28%
Researcher 40 21%
Student > Master 22 11%
Student > Bachelor 12 6%
Professor > Associate Professor 12 6%
Other 28 15%
Unknown 25 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 75 39%
Biochemistry, Genetics and Molecular Biology 72 38%
Immunology and Microbiology 6 3%
Design 2 1%
Medicine and Dentistry 2 1%
Other 5 3%
Unknown 30 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2021.
All research outputs
#13,385,646
of 22,711,645 outputs
Outputs from Epigenetics & Chromatin
#370
of 563 outputs
Outputs of similar age
#104,078
of 197,511 outputs
Outputs of similar age from Epigenetics & Chromatin
#7
of 13 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 563 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,511 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.