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Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women

Overview of attention for article published in Reproductive Biology and Endocrinology, October 2006
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Title
Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women
Published in
Reproductive Biology and Endocrinology, October 2006
DOI 10.1186/1477-7827-4-s1-s9
Pubmed ID
Authors

Bruce A Lessey, Wilder A Palomino, KBC Apparao, Steven L Young, Ruth A Lininger

Abstract

Endometriosis is a disorder that affects 5% of the normal population but is present in up to 40% of women with pelvic pain and/or infertility. Recent evidence suggests that the endometrium of women with endometriosis exhibits progesterone insensitivity. One endometrial protein that fluctuates in response to progesterone is the estrogen receptor-alpha (ER alpha), being down-regulated at the time of peak progesterone secretion during the window of implantation. Here we demonstrate that the biomarker of uterine receptivity, beta 3 integrin subunit, is reduced or absent in some women with endometriosis and that such defects are accompanied by inappropriate over-expression of ER alpha during the mid-secretory phase. Using a well-differentiated endometrial cell line we showed that the beta 3 integrin protein is negatively regulated by estrogen and positively regulated by epidermal growth factor (EGF). By competing against estrogen with various selective estrogen receptor modulators (SERMs) and estrogen receptor agonists and antagonists, inhibition of expression of the beta 3 integrin by estrogen can be mitigated. In conclusion, we hypothesize that certain types of uterine receptivity defects may be caused by the loss of appropriate ER alpha down-regulation in the mid-secretory phase, leading to defects in uterine receptivity. Such changes might be effectively treated by timely administration of the appropriate anti-estrogens to artificially block ER alpha and restore normal patterns of gene expression. Such treatments will require further clinical studies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ukraine 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 17%
Student > Master 10 16%
Student > Ph. D. Student 8 13%
Student > Bachelor 7 11%
Other 6 10%
Other 9 14%
Unknown 12 19%
Readers by discipline Count As %
Medicine and Dentistry 18 29%
Biochemistry, Genetics and Molecular Biology 15 24%
Agricultural and Biological Sciences 9 14%
Veterinary Science and Veterinary Medicine 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 2 3%
Unknown 15 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2013.
All research outputs
#18,340,012
of 22,711,645 outputs
Outputs from Reproductive Biology and Endocrinology
#655
of 966 outputs
Outputs of similar age
#62,463
of 66,457 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#9
of 9 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 966 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,457 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.