↓ Skip to main content

A next-generation microarray further reveals stage-enriched gene expression pattern in the blood fluke Schistosoma japonicum

Overview of attention for article published in Parasites & Vectors, January 2017
Altmetric Badge

Mentioned by

twitter
3 X users

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
27 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
A next-generation microarray further reveals stage-enriched gene expression pattern in the blood fluke Schistosoma japonicum
Published in
Parasites & Vectors, January 2017
DOI 10.1186/s13071-016-1947-x
Pubmed ID
Authors

Pengfei Cai, Shuai Liu, Xianyu Piao, Nan Hou, Hong You, Donald P. McManus, Qijun Chen

Abstract

Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma, and ranks, in terms of disability-adjusted life years (DALYs), as the third most important neglected tropical disease. Schistosomes have several discrete life stages involving dramatic morphological changes during their development, which require subtle gene expression modulations to complete the complex life-cycle. In the current study, we employed a second generation schistosome DNA chip printed with the most comprehensive probe array for studying the Schistosoma japonicum transcriptome, to explore stage-associated gene expression in different developmental phases of S. japonicum. A total of 328, 95, 268 and 532 mRNA transcripts were enriched in cercariae, hepatic schistosomula, adult worms and eggs, respectively. In general, genes associated with transcriptional regulation, cell signalling and motor activity were readily expressed in cercariae; the expression of genes involved in neuronal activities, apoptosis and renewal was modestly upregulated in hepatic schistosomula; transcripts involved in egg production, nutrition metabolism and glycosylation were enriched in adult worms; while genes involved in cell division, microtubule-associated mobility, and host-parasite interplay were relatively highly expressed in eggs. The study further highlights the expressional features of stage-associated genes in schistosomes with high accuracy. The results provide a better perspective of the biological characteristics among different developmental stages, which may open new avenues for identification of novel vaccine candidates and the development of novel control interventions against schistosomiasis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 22%
Unspecified 5 19%
Student > Master 4 15%
Student > Postgraduate 2 7%
Student > Doctoral Student 1 4%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Unspecified 5 19%
Agricultural and Biological Sciences 4 15%
Biochemistry, Genetics and Molecular Biology 3 11%
Medicine and Dentistry 3 11%
Mathematics 1 4%
Other 4 15%
Unknown 7 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2017.
All research outputs
#17,855,900
of 22,931,367 outputs
Outputs from Parasites & Vectors
#3,833
of 5,480 outputs
Outputs of similar age
#294,407
of 421,506 outputs
Outputs of similar age from Parasites & Vectors
#73
of 122 outputs
Altmetric has tracked 22,931,367 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,480 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,506 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.