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Alternative splicing tends to avoid partial removals of protein-protein interaction sites

Overview of attention for article published in BMC Genomics, June 2013
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Title
Alternative splicing tends to avoid partial removals of protein-protein interaction sites
Published in
BMC Genomics, June 2013
DOI 10.1186/1471-2164-14-379
Pubmed ID
Authors

Alessio Colantoni, Valerio Bianchi, Pier Federico Gherardini, Gianpaolo Scalia Tomba, Gabriele Ausiello, Manuela Helmer-Citterich, Fabrizio Ferrè

Abstract

Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 8%
United States 1 4%
India 1 4%
Unknown 20 83%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 42%
Researcher 8 33%
Student > Master 3 13%
Professor 1 4%
Lecturer > Senior Lecturer 1 4%
Other 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 63%
Biochemistry, Genetics and Molecular Biology 3 13%
Physics and Astronomy 2 8%
Computer Science 2 8%
Veterinary Science and Veterinary Medicine 1 4%
Other 0 0%
Unknown 1 4%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2013.
All research outputs
#18,340,012
of 22,711,645 outputs
Outputs from BMC Genomics
#8,155
of 10,626 outputs
Outputs of similar age
#148,325
of 197,464 outputs
Outputs of similar age from BMC Genomics
#92
of 118 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,626 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.