Title |
Alternative splicing tends to avoid partial removals of protein-protein interaction sites
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Published in |
BMC Genomics, June 2013
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DOI | 10.1186/1471-2164-14-379 |
Pubmed ID | |
Authors |
Alessio Colantoni, Valerio Bianchi, Pier Federico Gherardini, Gianpaolo Scalia Tomba, Gabriele Ausiello, Manuela Helmer-Citterich, Fabrizio Ferrè |
Abstract |
Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS. |
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