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Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Overview of attention for article published in Cancer Nanotechnology, July 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
103 Dimensions

Readers on

mendeley
126 Mendeley
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Title
Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse
Published in
Cancer Nanotechnology, July 2012
DOI 10.1007/s12645-012-0029-9
Pubmed ID
Authors

Mi-Ran Choi, Rizia Bardhan, Katie J. Stanton-Maxey, Sunil Badve, Harikrishna Nakshatri, Keith M. Stantz, Ning Cao, Naomi J. Halas, Susan E. Clare

Abstract

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Egypt 2 2%
Canada 1 <1%
United States 1 <1%
Unknown 122 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 33%
Researcher 20 16%
Student > Bachelor 11 9%
Student > Master 10 8%
Student > Doctoral Student 6 5%
Other 19 15%
Unknown 19 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 21%
Chemistry 16 13%
Engineering 14 11%
Medicine and Dentistry 13 10%
Pharmacology, Toxicology and Pharmaceutical Science 11 9%
Other 20 16%
Unknown 25 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2013.
All research outputs
#3,099,953
of 17,391,055 outputs
Outputs from Cancer Nanotechnology
#8
of 92 outputs
Outputs of similar age
#29,163
of 163,861 outputs
Outputs of similar age from Cancer Nanotechnology
#2
of 3 outputs
Altmetric has tracked 17,391,055 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,861 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.