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Activity of peroxisomal enzymes, and levels of polyamines in LPA-transgenic mice on two different diets

Overview of attention for article published in Lipids in Health and Disease, October 2005
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Title
Activity of peroxisomal enzymes, and levels of polyamines in LPA-transgenic mice on two different diets
Published in
Lipids in Health and Disease, October 2005
DOI 10.1186/1476-511x-4-23
Pubmed ID
Authors

Knut A Eliassen, Bjørn P Brodal, Aud Svindland, Harald Osmundsen, Helle Rønning, Srdjan Djurovic, Kåre Berg

Abstract

In man, elevated levels of plasma plipoprotein (a) (Lp(a)) is a cardiovascular risk factor, and oxidized phospholipids are believed to play a role as modulators of inflammatory processes such as atherosclerosis. Polyamines are potent antioxidants and anti-inflammatory agents. It was therefore of interest to examine polyamines and their metabolism in LPA transgenic mice. Concentration of the polyamines putrescine, spermidine and spermine as well as the activity of peroxisomal polyamine oxidase and two other peroxisomal enzymes, acyl-CoA oxidase and catalase were measured. The mice were fed either a standard diet or a diet high in fat and cholesterol (HFHC). Some of the mice in each feeding group were in addition given aminoguanidine (AG), a specific inhibitor of diamine oxidase, which catalyses degradation of putrescine, and also inhibits non-enzymatic glycosylation of protein which is implicated in the aetiology of atherosclerosis in diabetic patients. Non-transgenic mice were used as controls.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 18%
Professor > Associate Professor 2 18%
Student > Doctoral Student 1 9%
Student > Ph. D. Student 1 9%
Professor 1 9%
Other 2 18%
Unknown 2 18%
Readers by discipline Count As %
Medicine and Dentistry 6 55%
Agricultural and Biological Sciences 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2013.
All research outputs
#2,899,885
of 3,630,112 outputs
Outputs from Lipids in Health and Disease
#337
of 427 outputs
Outputs of similar age
#67,532
of 85,363 outputs
Outputs of similar age from Lipids in Health and Disease
#23
of 32 outputs
Altmetric has tracked 3,630,112 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 427 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,363 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.