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Attention Score in Context
| Title |
Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort
|
|---|---|
| Published in |
Microbiome, January 2017
|
| DOI | 10.1186/s40168-016-0213-y |
| Pubmed ID | |
| Authors |
Cian J. Hill, Denise B. Lynch, Kiera Murphy, Marynka Ulaszewska, Ian B. Jeffery, Carol Anne O’Shea, Claire Watkins, Eugene Dempsey, Fulvio Mattivi, Kieran Tuohy, R. Paul Ross, C. Anthony Ryan, Paul W. O’ Toole, Catherine Stanton |
| Abstract |
The gut is the most extensively studied niche of the human microbiome. The aim of this study was to characterise the initial gut microbiota development of a cohort of breastfed infants (n = 192) from 1 to 24 weeks of age. V4-V5 region 16S rRNA amplicon Illumina sequencing and, in parallel, bacteriological culture. The metabolomic profile of infant urine at 4 weeks of age was also examined by LC-MS. Full-term (FT), spontaneous vaginally delivered (SVD) infants' microbiota remained stable at both phylum and genus levels during the 24-week period examined. FT Caesarean section (CS) infants displayed an increased faecal abundance of Firmicutes (p < 0.01) and lower abundance of Actinobacteria (p < 0.001) after the first week of life compared to FT-SVD infants. FT-CS infants gradually progressed to harbouring a microbiota closely resembling FT-SVD (which remained stable) by week 8 of life, which was maintained at week 24. The gut microbiota of preterm (PT) infants displayed a significantly greater abundance of Proteobacteria compared to FT infants (p < 0.001) at week 1. Metabolomic analysis of urine at week 4 indicated PT-CS infants have a functionally different metabolite profile than FT (both CS and SVD) infants. Co-inertia analysis showed co-variation between the urine metabolome and the faecal microbiota of the infants. Tryptophan and tyrosine metabolic pathways, as well as fatty acid and bile acid metabolism, were found to be affected by delivery mode and gestational age. These findings confirm that mode of delivery and gestational age both have significant effects on early neonatal microbiota composition. There is also a significant difference between the metabolite profile of FT and PT infants. Prolonged breastfeeding was shown to have a significant effect on the microbiota composition of FT-CS infants at 24 weeks of age, but interestingly not on that of FT-SVD infants. Twins had more similar microbiota to one another than between two random infants, reflecting the influence of similarities in both host genetics and the environment on the microbiota.. |
X Demographics
The data shown below were collected from the profiles of 47 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 8 | 17% |
| United States | 7 | 15% |
| France | 4 | 9% |
| Canada | 3 | 6% |
| Italy | 3 | 6% |
| United Kingdom | 3 | 6% |
| Netherlands | 2 | 4% |
| China | 1 | 2% |
| Sweden | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 13 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 62% |
| Scientists | 13 | 28% |
| Practitioners (doctors, other healthcare professionals) | 4 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 747 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| Denmark | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 740 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 103 | 14% |
| Researcher | 97 | 13% |
| Student > Bachelor | 96 | 13% |
| Student > Master | 95 | 13% |
| Student > Doctoral Student | 44 | 6% |
| Other | 114 | 15% |
| Unknown | 198 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 117 | 16% |
| Biochemistry, Genetics and Molecular Biology | 101 | 14% |
| Agricultural and Biological Sciences | 96 | 13% |
| Immunology and Microbiology | 67 | 9% |
| Nursing and Health Professions | 43 | 6% |
| Other | 93 | 12% |
| Unknown | 230 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2023.
All research outputs
#645,883
of 26,017,215 outputs
Outputs from Microbiome
#179
of 1,790 outputs
Outputs of similar age
#13,650
of 427,974 outputs
Outputs of similar age from Microbiome
#7
of 34 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,790 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 427,974 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.