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Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy

Overview of attention for article published in Virology Journal, January 2017
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  • Good Attention Score compared to outputs of the same age (66th percentile)

Mentioned by

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7 tweeters

Citations

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51 Dimensions

Readers on

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41 Mendeley
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Title
Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
Published in
Virology Journal, January 2017
DOI 10.1186/s12985-016-0674-4
Pubmed ID
Authors

Huiqiang Wang, Ke Li, Linlin Ma, Shuo Wu, Jin Hu, Haiyan Yan, Jiandong Jiang, Yuhuan Li

Abstract

The MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of MEK-ERK signaling pathway and autophagy is shown to impair EV71 replication. Berberine (BBR), an isoquinoline alkaloid isolated from Berberis vulgaris L., has been reported to have ability to regulate this signaling pathway and autophagy. Herein, we want to determine whether berberine can inhibit EV71 infection by downregulating the MEK/ERK signaling pathway and autophagy. The antiviral effect of berberine was determined by cytopathic effect (CPE) assay, western blotting assay and qRT-PCR assay. The mechanism of BBR anti-virus was determined by western blotting assay and immunofluorescence assay. We showed that berberine does-dependently reduced EV71 RNA and protein synthesis, which was, at least in part, the result of inhibition of activation of MEK/ERK signaling pathway. Furthermore, we found that berberine suppressed the EV71-induced autophagy by activating AKT protein and inhibiting the phosphorylation of JNK and PI3KIII. BBR inhibited EV71 replication by downregulating autophagy and MEK/ERK signaling pathway. These findings suggest that BBR may be a potential agent or supplement against EV71 infection.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 15%
Student > Ph. D. Student 5 12%
Student > Master 5 12%
Other 4 10%
Professor 3 7%
Other 8 20%
Unknown 10 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 20%
Immunology and Microbiology 5 12%
Medicine and Dentistry 4 10%
Agricultural and Biological Sciences 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 2 5%
Unknown 15 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2020.
All research outputs
#5,939,453
of 19,101,906 outputs
Outputs from Virology Journal
#677
of 2,730 outputs
Outputs of similar age
#125,402
of 375,093 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 19,101,906 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 2,730 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.9. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 375,093 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them