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Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

Overview of attention for article published in Molecular Neurodegeneration, June 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
70 Dimensions

Readers on

mendeley
65 Mendeley
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Title
Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
Published in
Molecular Neurodegeneration, June 2013
DOI 10.1186/1750-1326-8-18
Pubmed ID
Authors

Katherine D LaClair, Kebreten F Manaye, Dexter L Lee, Joanne S Allard, Alena V Savonenko, Juan C Troncoso, Philip C Wong

Abstract

Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein apolipoprotein-E (APOE), hold promise for the treatment of AD. The amount of APOE in the brain is regulated by nuclear receptors including retinoid X receptors (RXRs). Drugs that activate RXRs, including bexarotene, can increase APOE and ABCA1 production, and have been shown to decrease the Aβ burden and improve cognition in mouse models of Aβ amyloidosis. Although recent bexarotene studies failed to replicate the rapid clearance of Aβ from brains, behavioral and cognitive effects of this compound remain controversial.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 3%
Netherlands 1 2%
Unknown 62 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 22%
Researcher 14 22%
Student > Bachelor 8 12%
Student > Doctoral Student 6 9%
Professor 3 5%
Other 10 15%
Unknown 10 15%
Readers by discipline Count As %
Neuroscience 17 26%
Agricultural and Biological Sciences 10 15%
Biochemistry, Genetics and Molecular Biology 9 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 11%
Medicine and Dentistry 4 6%
Other 4 6%
Unknown 14 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2013.
All research outputs
#2,295,508
of 6,230,693 outputs
Outputs from Molecular Neurodegeneration
#178
of 327 outputs
Outputs of similar age
#35,982
of 99,432 outputs
Outputs of similar age from Molecular Neurodegeneration
#5
of 11 outputs
Altmetric has tracked 6,230,693 research outputs across all sources so far. This one has received more attention than most of these and is in the 61st percentile.
So far Altmetric has tracked 327 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 99,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.