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Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer

Overview of attention for article published in Journal of Translational Medicine, June 2013
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Title
Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer
Published in
Journal of Translational Medicine, June 2013
DOI 10.1186/1479-5876-11-147
Pubmed ID
Authors

Vincent Lavoué, Aurélie Thédrez, Jean Levêque, Fabrice Foucher, Sébastien Henno, Vincent Jauffret, Marc-Antoine Belaud-Rotureau, Veronique Catros, Florian Cabillic

Abstract

Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an antitumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This review focuses on the immune response and immune suppression in EOC. The immunological roles of chemotherapy and surgery in EOC are also described. Finally, we detail pilot data supporting the efficiency of immunotherapy in the treatment of EOC and the emerging concept that immunomodulation aimed at counteracting the immunosuppressive microenvironment must be associated with immunotherapy strategies.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
United Kingdom 1 1%
Netherlands 1 1%
Sweden 1 1%
Unknown 83 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 25%
Student > Ph. D. Student 13 15%
Student > Bachelor 12 13%
Student > Master 6 7%
Professor > Associate Professor 5 6%
Other 16 18%
Unknown 15 17%
Readers by discipline Count As %
Medicine and Dentistry 24 27%
Agricultural and Biological Sciences 21 24%
Biochemistry, Genetics and Molecular Biology 9 10%
Immunology and Microbiology 7 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 8 9%
Unknown 18 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2013.
All research outputs
#15,273,442
of 22,712,476 outputs
Outputs from Journal of Translational Medicine
#2,232
of 3,973 outputs
Outputs of similar age
#121,809
of 196,875 outputs
Outputs of similar age from Journal of Translational Medicine
#29
of 39 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,973 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,875 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.