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Mendeley readers
Attention Score in Context
| Title |
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
|
|---|---|
| Published in |
Molecular Cancer, March 2013
|
| DOI | 10.1186/1476-4598-12-23 |
| Pubmed ID | |
| Authors |
Laura Creevey, Jacqueline Ryan, Harry Harvey, Isabella M Bray, Maria Meehan, Adnan R Khan, Raymond L Stallings |
| Abstract |
Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive of neuroblastoma patient survival and has been reported as a tumor suppressor in a variety of other cancers. WEE1, a tyrosine kinase regulator of the cell cycle and predicted target of miR-497, has emerged as an oncogene in several cancer types and therefore represents an attractive potential target for novel therapy approaches in high-risk neuroblastoma. Our aim was to investigate the potential tumor suppressive role of miR-497 in high-risk neuroblastoma. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 4% |
| Unknown | 52 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 22% |
| Researcher | 9 | 17% |
| Student > Master | 8 | 15% |
| Professor | 3 | 6% |
| Other | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 17 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 17% |
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Agricultural and Biological Sciences | 8 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Computer Science | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 18 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2013.
All research outputs
#20,195,024
of 22,712,476 outputs
Outputs from Molecular Cancer
#1,474
of 1,716 outputs
Outputs of similar age
#172,931
of 197,773 outputs
Outputs of similar age from Molecular Cancer
#6
of 7 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,716 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,773 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.