Title |
Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer’s disease
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Published in |
Lipids in Health and Disease, November 2012
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DOI | 10.1186/1476-511x-11-163 |
Pubmed ID | |
Authors |
Zhijie Xiao, Juan Wang, Weirong Chen, Peng Wang, Houlin Zeng, Weixi Chen |
Abstract |
Accumulating evidence suggested that dysregulation of cholesterol homeostasis might be a major etiologic factor in initiating and promoting neurodegeneration in Alzheimer's disease (AD). ATP-binding cassette transporter A1 (ABCA1), hepatic lipase (HL, coding genes named LIPC) and cholesteryl ester transfer protein (CETP) are important components of high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) implicated in atherosclerosis and neurodegenerative diseases. In the present study, we will investigate the possible association of several common polymorphisms (ABCA1R219K, CETPTaqIB and LIPC-250 G/A) with susceptibility to AD and plasma lipid levels. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Czechia | 1 | 2% |
Italy | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 20% |
Student > Ph. D. Student | 10 | 18% |
Student > Bachelor | 9 | 16% |
Student > Postgraduate | 6 | 11% |
Researcher | 3 | 5% |
Other | 8 | 15% |
Unknown | 8 | 15% |
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Other | 6 | 11% |
Unknown | 12 | 22% |