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Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: evidence of possible mediation by host tRNA-derived small noncoding RNAs

Overview of attention for article published in BMC Infectious Diseases, June 2013
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Title
Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: evidence of possible mediation by host tRNA-derived small noncoding RNAs
Published in
BMC Infectious Diseases, June 2013
DOI 10.1186/1471-2334-13-285
Pubmed ID
Authors

Bin Gong, Yong Sun Lee, Inhan Lee, Thomas R Shelite, Nawapol Kunkeaw, Guang Xu, Kwanbok Lee, Sung Ho Jeon, Betty H Johnson, Qing Chang, Tuha Ha, Nicole L Mendell, Xiaodong Cheng, Donald H Bouyer, Paul J Boor, Thomas G Ksiazek, David H Walker

Abstract

Microvascular endothelial barrier dysfunction is the central enigma in spotted fever group (SFG) rickettsioses. Angiogenin (ANG) is one of the earliest identified angiogenic factors, of which some are relevant to the phosphorylation of VE-cadherins that serve as endothelial adherens proteins. Although exogenous ANG is known to translocate into the nucleus of growing endothelial cells (ECs) where it plays a functional role, nuclear ANG is not detected in quiescent ECs. Besides its nuclear role, ANG is thought to play a cytoplasmic role, owing to its RNase activity that cleaves tRNA to produce small RNAs. Recently, such tRNA-derived RNA fragments (tRFs) have been shown to be induced under stress conditions. All these observations raise an intriguing hypothesis about a novel cytoplasmic role of ANG, which is induced upon infection with Rickettsia and generates tRFs that may play roles in SFG rickettsioses.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 4%
Argentina 1 2%
Unknown 46 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Student > Master 9 18%
Researcher 7 14%
Student > Doctoral Student 6 12%
Professor > Associate Professor 5 10%
Other 5 10%
Unknown 8 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 31%
Biochemistry, Genetics and Molecular Biology 14 29%
Medicine and Dentistry 3 6%
Immunology and Microbiology 2 4%
Business, Management and Accounting 1 2%
Other 5 10%
Unknown 9 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2013.
All research outputs
#20,195,024
of 22,712,476 outputs
Outputs from BMC Infectious Diseases
#6,438
of 7,657 outputs
Outputs of similar age
#172,253
of 196,664 outputs
Outputs of similar age from BMC Infectious Diseases
#113
of 152 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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