Title |
Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: evidence of possible mediation by host tRNA-derived small noncoding RNAs
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Published in |
BMC Infectious Diseases, June 2013
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DOI | 10.1186/1471-2334-13-285 |
Pubmed ID | |
Authors |
Bin Gong, Yong Sun Lee, Inhan Lee, Thomas R Shelite, Nawapol Kunkeaw, Guang Xu, Kwanbok Lee, Sung Ho Jeon, Betty H Johnson, Qing Chang, Tuha Ha, Nicole L Mendell, Xiaodong Cheng, Donald H Bouyer, Paul J Boor, Thomas G Ksiazek, David H Walker |
Abstract |
Microvascular endothelial barrier dysfunction is the central enigma in spotted fever group (SFG) rickettsioses. Angiogenin (ANG) is one of the earliest identified angiogenic factors, of which some are relevant to the phosphorylation of VE-cadherins that serve as endothelial adherens proteins. Although exogenous ANG is known to translocate into the nucleus of growing endothelial cells (ECs) where it plays a functional role, nuclear ANG is not detected in quiescent ECs. Besides its nuclear role, ANG is thought to play a cytoplasmic role, owing to its RNase activity that cleaves tRNA to produce small RNAs. Recently, such tRNA-derived RNA fragments (tRFs) have been shown to be induced under stress conditions. All these observations raise an intriguing hypothesis about a novel cytoplasmic role of ANG, which is induced upon infection with Rickettsia and generates tRFs that may play roles in SFG rickettsioses. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 2 | 4% |
Argentina | 1 | 2% |
Unknown | 46 | 94% |
Demographic breakdown
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Student > Ph. D. Student | 9 | 18% |
Student > Master | 9 | 18% |
Researcher | 7 | 14% |
Student > Doctoral Student | 6 | 12% |
Professor > Associate Professor | 5 | 10% |
Other | 5 | 10% |
Unknown | 8 | 16% |
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Medicine and Dentistry | 3 | 6% |
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Business, Management and Accounting | 1 | 2% |
Other | 5 | 10% |
Unknown | 9 | 18% |