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DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control

Overview of attention for article published in BMC Biology, June 2013
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Title
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Published in
BMC Biology, June 2013
DOI 10.1186/1741-7007-11-73
Pubmed ID
Authors

Xi Chen, Jia Chen, Siting Gan, Huaji Guan, Yuan Zhou, Qi Ouyang, Jue Shi

Abstract

The p53 pathway is differentially activated in response to distinct DNA damage, leading to alternative phenotypic outcomes in mammalian cells. Recent evidence suggests that p53 expression dynamics play an important role in the differential regulation of cell fate, but questions remain as to how p53 dynamics and the subsequent cellular response are modulated by variable DNA damage.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
Unknown 101 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 29%
Student > Bachelor 17 17%
Researcher 12 12%
Student > Master 9 9%
Professor > Associate Professor 7 7%
Other 15 15%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 30%
Biochemistry, Genetics and Molecular Biology 30 29%
Physics and Astronomy 7 7%
Engineering 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 12 12%
Unknown 13 13%