Title |
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
|
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Published in |
Retrovirology, June 2013
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DOI | 10.1186/1742-4690-10-65 |
Pubmed ID | |
Authors |
Eleftherios Michailidis, Emily M Ryan, Atsuko Hachiya, Karen A Kirby, Bruno Marchand, Maxwell D Leslie, Andrew D Huber, Yee T Ong, Jacob C Jackson, Kamalendra Singh, Eiichi N Kodama, Hiroaki Mitsuya, Michael A Parniak, Stefan G Sarafianos |
Abstract |
The K65R substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is the major resistance mutation selected in patients treated with first-line antiretroviral tenofovir disoproxil fumarate (TDF). 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), is the most potent nucleoside analog RT inhibitor (NRTI) that unlike all approved NRTIs retains a 3'-hydroxyl group and has remarkable potency against wild-type (WT) and drug-resistant HIVs. EFdA acts primarily as a chain terminator by blocking translocation following its incorporation into the nascent DNA chain. EFdA is in preclinical development and its effect on clinically relevant drug resistant HIV strains is critically important for the design of optimal regimens prior to initiation of clinical trials. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 25% |
Japan | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 24% |
Researcher | 7 | 19% |
Other | 3 | 8% |
Student > Postgraduate | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 5 | 14% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 30% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Immunology and Microbiology | 3 | 8% |
Agricultural and Biological Sciences | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Other | 6 | 16% |
Unknown | 7 | 19% |