Title |
Association between central blood pressure, arterial stiffness, and mild cognitive impairment
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Published in |
Clinical Hypertension, January 2017
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DOI | 10.1186/s40885-016-0058-5 |
Pubmed ID | |
Authors |
R. Suleman, R. Padwal, P. Hamilton, A. Senthilselvan, K. Alagiakrishnan |
Abstract |
To determine the relationship between central blood pressure (CBP) indices and mild cognitive impairment (MCI) in adults over the age of 50. A cross-sectional study conducted using a non-invasive SphygmoCor XCEL device. CBP indices and brachial blood pressure were measured in 50 inpatients and outpatients. MCI was assessed using the Montreal Cognitive Assessment (MoCA) instrument and by the European Consortium Criteria (ECC). Seventy-six percent of subjects had hypertension, and 52% were diagnosed as having MCI using the ECC. No significant association was found between any of the measured blood pressure variables and global cognition. A significant relationship was observed between augmentation index (AI) and abnormal clock-drawing (p = 0.04) and language (p = 0.02), and between pulse pressure amplification (PPA) and language (p = 0.03). CBP indices like AI and PPA, which are markers of vascular stiffness, are associated with poor executive function and language cognitive domain deficits. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 16% |
Student > Doctoral Student | 5 | 12% |
Researcher | 5 | 12% |
Other | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 5 | 12% |
Unknown | 14 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 30% |
Agricultural and Biological Sciences | 3 | 7% |
Psychology | 2 | 5% |
Neuroscience | 2 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 14% |
Unknown | 16 | 37% |