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Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast

Overview of attention for article published in BMC Genomics, January 2017
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Title
Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast
Published in
BMC Genomics, January 2017
DOI 10.1186/s12864-017-3509-9
Pubmed ID
Authors

Conor P. Young, Cory Hillyer, Karsten Hokamp, Darren J. Fitzpatrick, Nikifor K. Konstantinov, Jacqueline S. Welty, Scott A. Ness, Margaret Werner-Washburne, Alastair B. Fleming, Mary Ann Osley

Abstract

Quiescent cells have a low level of gene activity compared to growing cells. Using a yeast model for cellular quiescence, we defined the genome-wide profiles of three species of histone methylation associated with active transcription between growing and quiescent cells, and correlated these profiles with the presence of RNA polymerase II and transcripts. Quiescent cells retained histone methylations normally associated with transcriptionally active chromatin and had many transcripts in common with growing cells. Quiescent cells also contained significant levels of RNA polymerase II, but only low levels of the canonical initiating and elongating forms of the polymerase. The RNA polymerase II associated with genes in quiescent cells displayed a distinct occupancy profile compared to its pattern of occupancy across genes in actively growing cells. Although transcription is generally repressed in quiescent cells, analysis of individual genes identified a period of active transcription during the development of quiescence. The data suggest that the transcript profile and histone methylation marks in quiescent cells were established both in growing cells and during the development of quiescence and then retained in these cells. Together, this might ensure that quiescent cells can rapidly adapt to a changing environment to resume growth.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 18%
Researcher 7 16%
Student > Bachelor 6 14%
Student > Ph. D. Student 6 14%
Student > Postgraduate 3 7%
Other 6 14%
Unknown 8 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 30%
Agricultural and Biological Sciences 12 27%
Medicine and Dentistry 5 11%
Neuroscience 3 7%
Nursing and Health Professions 1 2%
Other 2 5%
Unknown 8 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2017.
All research outputs
#7,033,452
of 23,655,983 outputs
Outputs from BMC Genomics
#3,115
of 10,778 outputs
Outputs of similar age
#128,822
of 421,906 outputs
Outputs of similar age from BMC Genomics
#75
of 208 outputs
Altmetric has tracked 23,655,983 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 10,778 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 208 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.