Title |
The sense behind retroviral anti-sense transcription
|
---|---|
Published in |
Virology Journal, January 2017
|
DOI | 10.1186/s12985-016-0667-3 |
Pubmed ID | |
Authors |
Mamneet Manghera, Alycia Magnusson, Renée N. Douville |
Abstract |
Retroviruses are known to rely extensively on the expression of viral proteins from the sense proviral genomic strand. Yet, the production of regulatory retroviral proteins from antisense-encoded viral genes is gaining research attention, due to their clinical significance. This report will discuss what is known about antisense transcription in Retroviridae, and provide new information about antisense transcriptional regulation through a comparison of Human Immunodeficiency Virus (HIV), Human T-cell Lymphotrophic Virus (HTLV-1) and endogenous retrovirus-K (ERVK) long terminal repeats (LTRs). We will attempt to demonstrate that the potential for antisense transcription is more widespread within retroviruses than has been previously appreciated, with this feature being the rule, rather than the exception. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 11 | 22% |
Student > Ph. D. Student | 8 | 16% |
Researcher | 8 | 16% |
Student > Master | 7 | 14% |
Student > Doctoral Student | 3 | 6% |
Other | 5 | 10% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 38% |
Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Medicine and Dentistry | 4 | 8% |
Veterinary Science and Veterinary Medicine | 3 | 6% |
Immunology and Microbiology | 3 | 6% |
Other | 5 | 10% |
Unknown | 8 | 16% |