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Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

Overview of attention for article published in BMC Molecular and Cell Biology, June 2013
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Title
Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila
Published in
BMC Molecular and Cell Biology, June 2013
DOI 10.1186/1471-2121-14-29
Pubmed ID
Authors

Péter Lőw, Ágnes Varga, Karolina Pircs, Péter Nagy, Zsuzsanna Szatmári, Miklós Sass, Gábor Juhász

Abstract

Two pathways are responsible for the majority of regulated protein catabolism in eukaryotic cells: the ubiquitin-proteasome system (UPS) and lysosomal self-degradation through autophagy. Both processes are necessary for cellular homeostasis by ensuring continuous turnover and quality control of most intracellular proteins. Recent studies established that both UPS and autophagy are capable of selectively eliminating ubiquitinated proteins and that autophagy may partially compensate for the lack of proteasomal degradation, but the molecular links between these pathways are poorly characterized.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 1%
United States 1 1%
Uruguay 1 1%
Canada 1 1%
Unknown 94 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 42%
Researcher 21 21%
Student > Master 11 11%
Student > Bachelor 8 8%
Student > Doctoral Student 3 3%
Other 4 4%
Unknown 10 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 36 37%
Agricultural and Biological Sciences 35 36%
Neuroscience 5 5%
Medicine and Dentistry 4 4%
Immunology and Microbiology 3 3%
Other 4 4%
Unknown 11 11%