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Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice

Overview of attention for article published in BMC Neuroscience, June 2013
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice
Published in
BMC Neuroscience, June 2013
DOI 10.1186/1471-2202-14-63
Pubmed ID
Authors

Fabíola de Carvalho Chaves de Siqueira Mendes, Marina Negrão Frota de Almeida, André Pinheiro Gurgel Felício, Ana Carla Fadel, Diego de Jesus Silva, Thaíssa Gomes Borralho, Rodrigo Perez da Silva, João Bento-Torres, Pedro Fernando da Costa Vasconcelos, Victor Hugh Perry, Edson Marcos Leal Soares Ramos, Cristovam Wanderley Picanço-Diniz, Marcia Consentino Kronka Sosthenes

Abstract

To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of environmental enrichment and masticatory rehabilitation in recovering spatial learning at adulthood and in later life. For 6 months (6M) or 18 months (18M), we fed three groups of mice from postnatal day 21 respectively with a hard diet (HD) of pellets; pellets followed by a powdered, soft diet (HD/SD, divided into equal periods); or pellets followed by powder, followed by pellets again (HD/SD/HD, divided into equal periods). To mimic sedentary or active lifestyles, half of the animals from each group were raised from weaning in standard cages (impoverished environment; IE) and the other half in enriched cages (enriched environment; EE). To evaluate spatial learning, we used the Morris water maze.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 1%
United Kingdom 1 1%
Canada 1 1%
Unknown 71 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 19%
Student > Bachelor 9 12%
Student > Ph. D. Student 8 11%
Student > Doctoral Student 7 9%
Researcher 6 8%
Other 18 24%
Unknown 12 16%
Readers by discipline Count As %
Medicine and Dentistry 14 19%
Agricultural and Biological Sciences 10 14%
Sports and Recreations 9 12%
Psychology 9 12%
Neuroscience 7 9%
Other 10 14%
Unknown 15 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2013.
All research outputs
#6,926,808
of 22,713,403 outputs
Outputs from BMC Neuroscience
#337
of 1,241 outputs
Outputs of similar age
#59,315
of 195,446 outputs
Outputs of similar age from BMC Neuroscience
#13
of 52 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,241 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,446 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.