Title |
Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial
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Published in |
BMC Pregnancy and Childbirth, January 2017
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DOI | 10.1186/s12884-016-1215-2 |
Pubmed ID | |
Authors |
Minyanga Nkhoma, Per Ashorn, Ulla Ashorn, Kathryn G. Dewey, Austrida Gondwe, John Mbotwa, Stephen Rogerson, Steve M. Taylor, Kenneth Maleta |
Abstract |
Maternal infections are associated with maternal and foetal adverse outcomes. Nutrient supplementation during pregnancy may reduce the occurrence of infections by improving maternal immunity. We aimed to investigate the impact of small-quantity lipid-based nutrient supplement (SQ-LNS) on the occurrence of Plasmodium falciparum parasitaemia during pregnancy and trichomoniasis, vaginal candidiasis and urinary tract infection (UTI) after delivery. Pregnant Malawian women enrolled in the iLiNS-DYAD trial receiving daily supplementation with SQ-LNS, multiple micronutrients (MMN) or iron & folic acid (IFA) from <20 gestation weeks (gw) were assessed for P. falciparum parasitaemia at 32 gw using rapid diagnostic testing (RDT), at 36 gw using polymerase chain reaction (PCR) and at delivery using both RDT and PCR; and at one week after delivery for trichomoniasis and vaginal candidiasis using wet mount microscopy and for UTI using urine dipstick analysis. The prevalence of each infection by intervention group was estimated at the prescribed time points and the global null hypothesis was tested using logistic regression. Adjusted analyses were performed using preselected covariates. The prevalence of P. falciparum parasitaemia was 10.7% at 32 gw, 9% at 36 gw, and 8.3% by RDT and 20.2% by PCR at delivery. After delivery the prevalence of trichomoniasis was 10.5%, vaginal candidiasis was 0.5%, and UTI was 3.1%. There were no differences between intervention groups in the prevalence of any of the infections. In this population, SQ-LNS did not influence the occurrence of maternal P. falciparum parasitaemia, trichomoniasis, vaginal candidiasis or UTI. Identifier: NCT01239693 (10 November 2010). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 97 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 15% |
Student > Master | 15 | 15% |
Student > Bachelor | 14 | 14% |
Student > Ph. D. Student | 10 | 10% |
Unspecified | 5 | 5% |
Other | 14 | 14% |
Unknown | 24 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 20% |
Nursing and Health Professions | 15 | 15% |
Design | 5 | 5% |
Agricultural and Biological Sciences | 4 | 4% |
Social Sciences | 4 | 4% |
Other | 19 | 20% |
Unknown | 31 | 32% |