Title |
Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study
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Published in |
BMC Infectious Diseases, June 2013
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DOI | 10.1186/1471-2334-13-293 |
Pubmed ID | |
Authors |
Eric Bonnet, Jean-Bernard Ruidavets, Anne Genoux, Laurence Mabile, Florian Busato, Martine Obadia, François Prévoteau, Bruno Marchou, Patrice Massip, Fabrice Marion-Latard, Cyrille Delpierre, Jacques Bernard, Bertrand Perret |
Abstract |
HIV-infected patients starting antiretroviral treatment (ART) experience deep and early disorders in fat and bone metabolism, leading to concomitant changes in fat mass and bone mineral density METHODS: We conducted a prospective study in treatment-naive HIV-infected patients randomized to receive two nucleoside reverse transcriptase inhibitors in combination with either a protease inhibitor (PI) or a non-nucleosidic reverse transcriptase inhibitor (NNRTI), to evaluate early changes in body composition, bone mineral density and metabolic markers as differentially induced by antiretroviral therapies. We measured changes in markers of carbohydrate, of fat and bone metabolism, and, using dual-emission X-ray absorptiometry (DXA), body composition and bone mineral density (BMD). Complete data on changes between baseline and after 21 months treatment were available for 35 patients (16 in the PI group and 19 in the NNRTI group). |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 67 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 18 | 27% |
Student > Bachelor | 11 | 16% |
Student > Doctoral Student | 6 | 9% |
Student > Postgraduate | 5 | 7% |
Student > Ph. D. Student | 5 | 7% |
Other | 12 | 18% |
Unknown | 10 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 30 | 45% |
Nursing and Health Professions | 5 | 7% |
Agricultural and Biological Sciences | 5 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 5 | 7% |
Unknown | 17 | 25% |