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Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study

Overview of attention for article published in BMC Infectious Diseases, June 2013
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Title
Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study
Published in
BMC Infectious Diseases, June 2013
DOI 10.1186/1471-2334-13-293
Pubmed ID
Authors

Eric Bonnet, Jean-Bernard Ruidavets, Anne Genoux, Laurence Mabile, Florian Busato, Martine Obadia, François Prévoteau, Bruno Marchou, Patrice Massip, Fabrice Marion-Latard, Cyrille Delpierre, Jacques Bernard, Bertrand Perret

Abstract

HIV-infected patients starting antiretroviral treatment (ART) experience deep and early disorders in fat and bone metabolism, leading to concomitant changes in fat mass and bone mineral density METHODS: We conducted a prospective study in treatment-naive HIV-infected patients randomized to receive two nucleoside reverse transcriptase inhibitors in combination with either a protease inhibitor (PI) or a non-nucleosidic reverse transcriptase inhibitor (NNRTI), to evaluate early changes in body composition, bone mineral density and metabolic markers as differentially induced by antiretroviral therapies. We measured changes in markers of carbohydrate, of fat and bone metabolism, and, using dual-emission X-ray absorptiometry (DXA), body composition and bone mineral density (BMD). Complete data on changes between baseline and after 21 months treatment were available for 35 patients (16 in the PI group and 19 in the NNRTI group).

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 27%
Student > Bachelor 11 16%
Student > Doctoral Student 6 9%
Student > Postgraduate 5 7%
Student > Ph. D. Student 5 7%
Other 12 18%
Unknown 10 15%
Readers by discipline Count As %
Medicine and Dentistry 30 45%
Nursing and Health Professions 5 7%
Agricultural and Biological Sciences 5 7%
Biochemistry, Genetics and Molecular Biology 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 5 7%
Unknown 17 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2013.
All research outputs
#20,195,877
of 22,713,403 outputs
Outputs from BMC Infectious Diseases
#6,438
of 7,657 outputs
Outputs of similar age
#171,425
of 195,446 outputs
Outputs of similar age from BMC Infectious Diseases
#114
of 152 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,657 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.