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Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study

Overview of attention for article published in BMC Medical Genetics, January 2017
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  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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3 tweeters

Citations

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9 Dimensions

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23 Mendeley
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Title
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study
Published in
BMC Medical Genetics, January 2017
DOI 10.1186/s12881-016-0366-3
Pubmed ID
Authors

Geetha Chittoor, Karin Haack, Nitesh R. Mehta, Sandra Laston, Shelley A. Cole, Anthony G. Comuzzie, Nancy F. Butte, V. Saroja Voruganti

Abstract

Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study. We performed a genome-wide association analysis for 24-h urinary excretion measures such as urinary uric acid/urinary creatinine ratio, uric acid clearance, fractional excretion of uric acid, and glomerular load of uric acid in SOLAR, while accounting for non-independence among family members. All renal urate excretion measures were significantly heritable (p <2 × 10(-6)) and ranged from 0.41 to 0.74. Empirical threshold for genome-wide significance was set at p <1 × 10(-7). We observed a strong association (p < 8 × 10(-8)) of uric acid clearance with a single nucleotide polymorphism (SNP) in zinc finger protein 446 (ZNF446) (rs2033711 (A/G), MAF: 0.30). The minor allele (G) was associated with increased uric acid clearance. Also, we found suggestive associations of uric acid clearance with SNPs in ZNF324, ZNF584, and ZNF132 (in a 72 kb region of 19q13; p <1 × 10(-6), MAFs: 0.28-0.31). For the first time, we showed the importance of 19q13 region in the regulation of renal urate excretion in Hispanic children. Our findings indicate differences in inherent genetic architecture and shared environmental risk factors between our cohort and other pediatric and adult populations.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 13%
Student > Bachelor 3 13%
Professor > Associate Professor 2 9%
Student > Master 2 9%
Student > Doctoral Student 1 4%
Other 5 22%
Unknown 7 30%
Readers by discipline Count As %
Medicine and Dentistry 6 26%
Nursing and Health Professions 5 22%
Biochemistry, Genetics and Molecular Biology 5 22%
Unknown 7 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2017.
All research outputs
#3,789,858
of 9,105,319 outputs
Outputs from BMC Medical Genetics
#175
of 607 outputs
Outputs of similar age
#120,875
of 311,934 outputs
Outputs of similar age from BMC Medical Genetics
#2
of 8 outputs
Altmetric has tracked 9,105,319 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 607 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,934 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.