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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2
|
|---|---|
| Published in |
Cancer Cell International, May 2009
|
| DOI | 10.1186/1475-2867-9-14 |
| Pubmed ID | |
| Authors |
Eugene J Fine, Anna Miller, Edward V Quadros, Jeffrey M Sequeira, Richard D Feinman |
| Abstract |
Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid (TCA) enzymes. The goal of the current study was to test the hypothesis that ketone bodies can inhibit cell growth in aggressive cancers and that expression of uncoupling protein 2 is a contributing factor. The proposed mechanism involves inhibition of glycolytic ATP production via a Randle-like cycle while increased uncoupling renders cancers unable to produce compensatory ATP from respiration. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Germany | 1 | 1% |
| Unknown | 94 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 18% |
| Researcher | 14 | 14% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Bachelor | 8 | 8% |
| Other | 8 | 8% |
| Other | 22 | 23% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 19% |
| Medicine and Dentistry | 17 | 18% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Chemistry | 8 | 8% |
| Nursing and Health Professions | 6 | 6% |
| Other | 19 | 20% |
| Unknown | 20 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2022.
All research outputs
#1,797,029
of 25,371,288 outputs
Outputs from Cancer Cell International
#26
of 2,231 outputs
Outputs of similar age
#5,772
of 125,259 outputs
Outputs of similar age from Cancer Cell International
#2
of 5 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,231 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.