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Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2

Overview of attention for article published in Cancer Cell International, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 992)
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters
patent
2 patents

Citations

dimensions_citation
59 Dimensions

Readers on

mendeley
81 Mendeley
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Title
Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2
Published in
Cancer Cell International, January 2009
DOI 10.1186/1475-2867-9-14
Pubmed ID
Authors

Eugene J Fine, Anna Miller, Edward V Quadros, Jeffrey M Sequeira, Richard D Feinman

Abstract

Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid (TCA) enzymes. The goal of the current study was to test the hypothesis that ketone bodies can inhibit cell growth in aggressive cancers and that expression of uncoupling protein 2 is a contributing factor. The proposed mechanism involves inhibition of glycolytic ATP production via a Randle-like cycle while increased uncoupling renders cancers unable to produce compensatory ATP from respiration.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Germany 1 1%
Unknown 78 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 20%
Researcher 12 15%
Other 9 11%
Student > Ph. D. Student 8 10%
Student > Bachelor 8 10%
Other 20 25%
Unknown 8 10%
Readers by discipline Count As %
Medicine and Dentistry 18 22%
Agricultural and Biological Sciences 17 21%
Chemistry 8 10%
Biochemistry, Genetics and Molecular Biology 7 9%
Nursing and Health Professions 6 7%
Other 16 20%
Unknown 9 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2018.
All research outputs
#1,284,580
of 17,501,053 outputs
Outputs from Cancer Cell International
#6
of 992 outputs
Outputs of similar age
#12,918
of 163,596 outputs
Outputs of similar age from Cancer Cell International
#1
of 1 outputs
Altmetric has tracked 17,501,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 992 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,596 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them