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Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent

Overview of attention for article published in Parasites & Vectors, January 2017
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Title
Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent
Published in
Parasites & Vectors, January 2017
DOI 10.1186/s13071-017-1980-4
Pubmed ID
Authors

Geoffrey E. Lynn, Jonathan D. Oliver, Ingrid Cornax, M. Gerard O’Sullivan, Ulrike G. Munderloh

Abstract

The Ehrlichia muris-like agent (EMLA) is a newly recognized human pathogen in the North Central United States. Although blacklegged ticks (Ixodes scapularis) have been identified as capable vectors, wild reservoirs have not yet been established for EMLA. As key hosts for I. scapularis, white-footed mice (Peromyscus leucopus) are important reservoirs for various tick-borne pathogens, and potentially, for EMLA. The objective of this study was to evaluate reservoir competence in P. leucopus using a natural vector. Mice acquired EMLA infection from feeding ticks and were able to transmit infection to naïve ticks. Transmission between simultaneously feeding tick life stages was also demonstrated. Infections in mice were acute and severe, with systemic dissemination. Limited host survival and clearance of infection among survivors resulted in a narrow interval where EMLA could be acquired by feeding ticks. Peromyscus leucopus is a competent reservoir of EMLA and likely to play a role in its enzootic transmission cycle. The duration and severity of EMLA infection in these hosts suggests that tick phenology is a critical factor determining the geographic distribution of EMLA in North America.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 27%
Researcher 4 15%
Student > Doctoral Student 2 8%
Student > Postgraduate 2 8%
Professor 1 4%
Other 3 12%
Unknown 7 27%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 7 27%
Biochemistry, Genetics and Molecular Biology 2 8%
Agricultural and Biological Sciences 2 8%
Immunology and Microbiology 2 8%
Computer Science 1 4%
Other 3 12%
Unknown 9 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2017.
All research outputs
#18,525,776
of 22,947,506 outputs
Outputs from Parasites & Vectors
#4,248
of 5,483 outputs
Outputs of similar age
#310,378
of 419,749 outputs
Outputs of similar age from Parasites & Vectors
#103
of 139 outputs
Altmetric has tracked 22,947,506 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,483 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,749 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.