Title |
Improved neurocognitive functions correlate with reduced inflammatory burden in atrial fibrillation patients treated with intensive cholesterol lowering therapy
|
---|---|
Published in |
Journal of Neuroinflammation, June 2013
|
DOI | 10.1186/1742-2094-10-78 |
Pubmed ID | |
Authors |
Knut Tore Lappegård, Monica Pop-Purceleanu, Waander van Heerde, Joe Sexton, Indira Tendolkar, Gheorghe Pop |
Abstract |
Atrial fibrillation (AF) is associated with increased mortality and morbidity, including risk for cerebral macro- and microinfarctions and cognitive decline, even in the presence of adequate oral anticoagulation. AF is strongly related to increased inflammatory activity whereby anti-inflammatory agents can reduce the risk of new or recurrent AF. However, it is not known whether anti-inflammatory therapy can also modify the deterioration of neurocognitive function in older patients with AF. In the present study, older patients with AF were treated with intensive lipid-lowering therapy with atorvastatin 40 mg and ezetimibe 10 mg, or placebo. We examined the relationship between neurocognitive functions and inflammatory burden. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 50% |
United States | 1 | 17% |
Mexico | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
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Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 3% |
United States | 1 | 1% |
Slovenia | 1 | 1% |
Unknown | 66 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 14% |
Student > Ph. D. Student | 9 | 13% |
Student > Master | 9 | 13% |
Researcher | 7 | 10% |
Student > Doctoral Student | 5 | 7% |
Other | 16 | 23% |
Unknown | 14 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 24% |
Psychology | 12 | 17% |
Neuroscience | 5 | 7% |
Agricultural and Biological Sciences | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 8 | 11% |
Unknown | 20 | 29% |