Title |
Simian virus 40 in humans
|
---|---|
Published in |
Infectious Agents and Cancer, July 2007
|
DOI | 10.1186/1750-9378-2-13 |
Pubmed ID | |
Authors |
Fernanda Martini, Alfredo Corallini, Veronica Balatti, Silvia Sabbioni, Cecilia Pancaldi, Mauro Tognon |
Abstract |
Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SV40-contaminated vaccines.SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors. Contrasting reports appeared in the literature on the circulation of SV40 in humans by contagious transmission and its association, as a possible etiologic cofactor, with specific human tumors. As a consequence of the conflicting results, a considerable debate has developed in the scientific community. In the present review we consider the main results obtained by different groups investigating SV40 sequences in human tumors and in blood specimens, the putative role of SV40 in the onset/progression of specific human tumors, and comment on the hypotheses arising from these data. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 39 | 18% |
United Kingdom | 13 | 6% |
Canada | 12 | 6% |
Australia | 4 | 2% |
Germany | 3 | 1% |
France | 2 | <1% |
New Zealand | 1 | <1% |
Cameroon | 1 | <1% |
India | 1 | <1% |
Other | 8 | 4% |
Unknown | 130 | 61% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 201 | 94% |
Scientists | 6 | 3% |
Practitioners (doctors, other healthcare professionals) | 6 | 3% |
Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 16% |
Student > Master | 9 | 16% |
Student > Bachelor | 9 | 16% |
Researcher | 6 | 11% |
Professor > Associate Professor | 5 | 9% |
Other | 12 | 21% |
Unknown | 7 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 25% |
Agricultural and Biological Sciences | 13 | 23% |
Biochemistry, Genetics and Molecular Biology | 11 | 19% |
Immunology and Microbiology | 3 | 5% |
Chemical Engineering | 1 | 2% |
Other | 6 | 11% |
Unknown | 9 | 16% |