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Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts

Overview of attention for article published in Genome Biology, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Citations

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167 Dimensions

Readers on

mendeley
250 Mendeley
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1 CiteULike
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Title
Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts
Published in
Genome Biology, January 2017
DOI 10.1186/s13059-016-1146-2
Pubmed ID
Authors

Jonas Paulsen, Monika Sekelja, Anja R. Oldenburg, Alice Barateau, Nolwenn Briand, Erwan Delbarre, Akshay Shah, Anita L. Sørensen, Corinne Vigouroux, Brigitte Buendia, Philippe Collas

Abstract

Current three-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positions of topologically-associated domains (TADs) relative to each other and to the nuclear periphery. Chrom3D integrates chromosome conformation capture (Hi-C) and lamin-associated domain (LAD) datasets to generate structure ensembles that recapitulate radial distributions of TADs detected in single cells. Chrom3D reveals unexpected spatial features of LAD regulation in cells from patients with a laminopathy-causing lamin mutation. Chrom3D is freely available on github.

X Demographics

X Demographics

The data shown below were collected from the profiles of 78 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 250 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 <1%
Korea, Republic of 1 <1%
Lithuania 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 245 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 70 28%
Researcher 54 22%
Student > Master 27 11%
Student > Bachelor 24 10%
Student > Doctoral Student 11 4%
Other 30 12%
Unknown 34 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 104 42%
Agricultural and Biological Sciences 68 27%
Computer Science 10 4%
Physics and Astronomy 9 4%
Medicine and Dentistry 5 2%
Other 16 6%
Unknown 38 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2018.
All research outputs
#906,167
of 25,382,440 outputs
Outputs from Genome Biology
#621
of 4,468 outputs
Outputs of similar age
#19,650
of 424,069 outputs
Outputs of similar age from Genome Biology
#12
of 61 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,468 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,069 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.