Title |
Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts
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Published in |
Genome Biology, January 2017
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DOI | 10.1186/s13059-016-1146-2 |
Pubmed ID | |
Authors |
Jonas Paulsen, Monika Sekelja, Anja R. Oldenburg, Alice Barateau, Nolwenn Briand, Erwan Delbarre, Akshay Shah, Anita L. Sørensen, Corinne Vigouroux, Brigitte Buendia, Philippe Collas |
Abstract |
Current three-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positions of topologically-associated domains (TADs) relative to each other and to the nuclear periphery. Chrom3D integrates chromosome conformation capture (Hi-C) and lamin-associated domain (LAD) datasets to generate structure ensembles that recapitulate radial distributions of TADs detected in single cells. Chrom3D reveals unexpected spatial features of LAD regulation in cells from patients with a laminopathy-causing lamin mutation. Chrom3D is freely available on github. |
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United Kingdom | 9 | 12% |
France | 5 | 6% |
Norway | 4 | 5% |
Germany | 3 | 4% |
Australia | 3 | 4% |
Spain | 2 | 3% |
Canada | 2 | 3% |
Singapore | 1 | 1% |
Other | 6 | 8% |
Unknown | 25 | 32% |
Demographic breakdown
Type | Count | As % |
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Scientists | 33 | 42% |
Science communicators (journalists, bloggers, editors) | 4 | 5% |
Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
Geographical breakdown
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Switzerland | 1 | <1% |
Korea, Republic of | 1 | <1% |
Lithuania | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 245 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 54 | 22% |
Student > Master | 27 | 11% |
Student > Bachelor | 24 | 10% |
Student > Doctoral Student | 11 | 4% |
Other | 30 | 12% |
Unknown | 34 | 14% |
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Computer Science | 10 | 4% |
Physics and Astronomy | 9 | 4% |
Medicine and Dentistry | 5 | 2% |
Other | 16 | 6% |
Unknown | 38 | 15% |