Title |
Jenner-predict server: prediction of protein vaccine candidates (PVCs) in bacteria based on host-pathogen interactions
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Published in |
BMC Bioinformatics, July 2013
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DOI | 10.1186/1471-2105-14-211 |
Pubmed ID | |
Authors |
Varun Jaiswal, Sree Krishna Chanumolu, Ankit Gupta, Rajinder S Chauhan, Chittaranjan Rout |
Abstract |
Subunit vaccines based on recombinant proteins have been effective in preventing infectious diseases and are expected to meet the demands of future vaccine development. Computational approach, especially reverse vaccinology (RV) method has enormous potential for identification of protein vaccine candidates (PVCs) from a proteome. The existing protective antigen prediction software and web servers have low prediction accuracy leading to limited applications for vaccine development. Besides machine learning techniques, those software and web servers have considered only protein's adhesin-likeliness as criterion for identification of PVCs. Several non-adhesin functional classes of proteins involved in host-pathogen interactions and pathogenesis are known to provide protection against bacterial infections. Therefore, knowledge of bacterial pathogenesis has potential to identify PVCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 25% |
United States | 1 | 25% |
Norway | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 104 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 14% |
Student > Master | 14 | 13% |
Student > Bachelor | 12 | 12% |
Researcher | 11 | 11% |
Other | 8 | 8% |
Other | 22 | 21% |
Unknown | 22 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 27% |
Biochemistry, Genetics and Molecular Biology | 20 | 19% |
Immunology and Microbiology | 10 | 10% |
Engineering | 5 | 5% |
Medicine and Dentistry | 3 | 3% |
Other | 10 | 10% |
Unknown | 28 | 27% |