Title |
Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells
|
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Published in |
BMC Musculoskeletal Disorders, July 2013
|
DOI | 10.1186/1471-2474-14-197 |
Pubmed ID | |
Authors |
Hiroki Yokota, Kazunori Hamamura, Andy Chen, Todd R Dodge, Nancy Tanjung, Aysan Abedinpoor, Ping Zhang |
Abstract |
Osteoporosis is a skeletal disease leading to an increased risk of bone fracture. Using a mouse osteoporosis model induced by administration of a receptor activator of nuclear factor kappa-B ligand (RANKL), salubrinal was recently reported as a potential therapeutic agent. To evaluate the role of salubrinal in cellular fates as well as migratory and adhesive functions of osteoclast/osteoblast precursors, we examined the development of primary bone marrow-derived cells in the presence and absence of salubrinal. We addressed a question: are salubrinal's actions more potent to the cells isolated from the osteoporotic mice than those isolated from the control mice? |
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Germany | 1 | 50% |
Demographic breakdown
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Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Student > Bachelor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
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Student > Master | 2 | 13% |
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Unknown | 1 | 7% |
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Other | 0 | 0% |
Unknown | 3 | 20% |