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HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors

Overview of attention for article published in BMC Veterinary Research, July 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
4 X users
googleplus
1 Google+ user

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
47 Mendeley
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Title
HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors
Published in
BMC Veterinary Research, July 2013
DOI 10.1186/1746-6148-9-130
Pubmed ID
Authors

Deanna D Dailey, Kristin P Anfinsen, Liza E Pfaff, EJ Ehrhart, J Brad Charles, Tina B Bønsdorff, Douglas H Thamm, Barbara E Powers, Thora J Jonasdottir, Dawn L Duval

Abstract

Hairy and enhancer of split 1 (HES1), a basic helix-loop-helix transcriptional repressor, is a downstream target of Notch signaling. Notch signaling and HES1 expression have been linked to growth and survival in a variety of human cancer types and have been associated with increased metastasis and invasiveness in human osteosarcoma cell lines. Osteosarcoma (OSA) is an aggressive cancer demonstrating both high metastatic rate and chemotherapeutic resistance. The current study examined expression of Notch signaling mediators in primary canine OSA tumors and canine and human osteosarcoma cell lines to assess their role in OSA development and progression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 15%
Student > Postgraduate 7 15%
Student > Ph. D. Student 6 13%
Student > Master 6 13%
Other 4 9%
Other 7 15%
Unknown 10 21%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 16 34%
Medicine and Dentistry 9 19%
Biochemistry, Genetics and Molecular Biology 3 6%
Agricultural and Biological Sciences 2 4%
Computer Science 1 2%
Other 3 6%
Unknown 13 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2013.
All research outputs
#1,749,247
of 22,713,403 outputs
Outputs from BMC Veterinary Research
#99
of 3,037 outputs
Outputs of similar age
#15,934
of 194,634 outputs
Outputs of similar age from BMC Veterinary Research
#1
of 38 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,037 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,634 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.