Title |
HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors
|
---|---|
Published in |
BMC Veterinary Research, July 2013
|
DOI | 10.1186/1746-6148-9-130 |
Pubmed ID | |
Authors |
Deanna D Dailey, Kristin P Anfinsen, Liza E Pfaff, EJ Ehrhart, J Brad Charles, Tina B Bønsdorff, Douglas H Thamm, Barbara E Powers, Thora J Jonasdottir, Dawn L Duval |
Abstract |
Hairy and enhancer of split 1 (HES1), a basic helix-loop-helix transcriptional repressor, is a downstream target of Notch signaling. Notch signaling and HES1 expression have been linked to growth and survival in a variety of human cancer types and have been associated with increased metastasis and invasiveness in human osteosarcoma cell lines. Osteosarcoma (OSA) is an aggressive cancer demonstrating both high metastatic rate and chemotherapeutic resistance. The current study examined expression of Notch signaling mediators in primary canine OSA tumors and canine and human osteosarcoma cell lines to assess their role in OSA development and progression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | 25% |
United Kingdom | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 15% |
Student > Postgraduate | 7 | 15% |
Student > Ph. D. Student | 6 | 13% |
Student > Master | 6 | 13% |
Other | 4 | 9% |
Other | 7 | 15% |
Unknown | 10 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 16 | 34% |
Medicine and Dentistry | 9 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Agricultural and Biological Sciences | 2 | 4% |
Computer Science | 1 | 2% |
Other | 3 | 6% |
Unknown | 13 | 28% |