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Host genetic variation in mucosal immunity pathways influences the upper airway microbiome

Overview of attention for article published in Microbiome, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

blogs
1 blog
twitter
14 tweeters
patent
1 patent
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
88 Mendeley
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Title
Host genetic variation in mucosal immunity pathways influences the upper airway microbiome
Published in
Microbiome, February 2017
DOI 10.1186/s40168-016-0227-5
Pubmed ID
Authors

Catherine Igartua, Emily R. Davenport, Yoav Gilad, Dan L. Nicolae, Jayant Pinto, Carole Ober

Abstract

The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder population of European decent. We estimated the relative abundances (RAs) of genus level bacteria from 16S rRNA gene sequences and examined associations with 148,653 genetic variants (linkage disequilibrium [LD] r (2) < 0.5) selected from among all common variants discovered in genome sequences in this population. We identified 37 microbiome quantitative trait loci (mbQTLs) that showed evidence of association with the RAs of 22 genera (q < 0.05) and were enriched for genes in mucosal immunity pathways. The most significant association was between the RA of Dermacoccus (phylum Actinobacteria) and a variant 8 kb upstream of TINCR (rs117042385; p = 1.61 × 10(-8); q = 0.002), a long non-coding RNA that binds to peptidoglycan recognition protein 3 (PGLYRP3) mRNA, a gene encoding a known antimicrobial protein. A second association was between a missense variant in PGLYRP4 (rs3006458) and the RA of an unclassified genus of family Micrococcaceae (phylum Actinobacteria) (p = 5.10 × 10(-7); q = 0.032). Our findings provide evidence of host genetic influences on upper airway microbial composition in humans and implicate mucosal immunity genes in this relationship.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 20%
Student > Ph. D. Student 16 18%
Student > Master 12 14%
Student > Bachelor 12 14%
Student > Doctoral Student 4 5%
Other 13 15%
Unknown 13 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 34%
Biochemistry, Genetics and Molecular Biology 20 23%
Medicine and Dentistry 9 10%
Immunology and Microbiology 5 6%
Arts and Humanities 2 2%
Other 6 7%
Unknown 16 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2021.
All research outputs
#1,153,135
of 18,763,644 outputs
Outputs from Microbiome
#421
of 1,128 outputs
Outputs of similar age
#31,350
of 373,560 outputs
Outputs of similar age from Microbiome
#5
of 10 outputs
Altmetric has tracked 18,763,644 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,128 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.2. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 373,560 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.