Title |
Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation
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Published in |
Epigenetics & Chromatin, July 2013
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DOI | 10.1186/1756-8935-6-19 |
Pubmed ID | |
Authors |
Arne W Mould, Zhenyi Pang, Miha Pakusch, Ian D Tonks, Mitchell Stark, Dianne Carrie, Pamela Mukhopadhyay, Annica Seidel, Jonathan J Ellis, Janine Deakin, Matthew J Wakefield, Lutz Krause, Marnie E Blewitt, Graham F Kay |
Abstract |
Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are less affected by Smchd1-loss, with some (but not all) surviving to become fertile adults on the FVB/n genetic background. On other genetic backgrounds, all males lacking Smchd1 die perinatally. This suggests that, in addition to being critical for X inactivation, Smchd1 functions to control the expression of essential autosomal genes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 40% |
United Kingdom | 1 | 20% |
United States | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Members of the public | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 1% |
Brazil | 1 | 1% |
Canada | 1 | 1% |
Japan | 1 | 1% |
United States | 1 | 1% |
Unknown | 76 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 25% |
Student > Master | 13 | 16% |
Researcher | 12 | 15% |
Student > Bachelor | 7 | 9% |
Professor | 5 | 6% |
Other | 9 | 11% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 38% |
Biochemistry, Genetics and Molecular Biology | 23 | 28% |
Neuroscience | 3 | 4% |
Chemistry | 2 | 2% |
Medicine and Dentistry | 2 | 2% |
Other | 5 | 6% |
Unknown | 15 | 19% |