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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability
|
|---|---|
| Published in |
Arthritis Research & Therapy, January 2017
|
| DOI | 10.1186/s13075-016-1215-7 |
| Pubmed ID | |
| Authors |
Kim M. Huffman, Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, Julie McCracken, Brian F. Gilmore, K. Noelle Tune, Milton Campbell, Timothy R. Koves, Deborah M. Muoio, Monica J. Hubal, William E. Kraus |
| Abstract |
To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. Persons with seropositive or erosive RA (n = 51) and control subjects matched for age, gender, race, body mass index (BMI), and physical activity (n = 51) underwent assessment of disease activity, disability, pain, physical activity and thigh muscle biopsies. Muscle tissue was used for measurement of pro-inflammatory markers, transcriptomics, and comprehensive profiling of metabolic intermediates. Groups were compared using mixed models. Bivariate associations were assessed with Spearman correlation. Compared to controls, patients with RA had 75% greater muscle concentrations of IL-6 protein (p = 0.006). In patients with RA, muscle concentrations of inflammatory markers were positively associated (p < 0.05 for all) with disease activity (IL-1β, IL-8), disability (IL-1β, IL-6), pain (IL-1β, TNF-α, toll-like receptor (TLR)-4), and physical inactivity (IL-1β, IL-6). Muscle cytokines were not related to corresponding systemic cytokines. Prominent among the gene sets differentially expressed in muscles in RA versus controls were those involved in skeletal muscle repair processes and glycolytic metabolism. Metabolic profiling revealed 46% higher concentrations of pyruvate in muscle in RA (p < 0.05), and strong positive correlation between levels of amino acids involved in fibrosis (arginine, ornithine, proline, and glycine) and disability (p < 0.05). RA is accompanied by broad-ranging molecular alterations in skeletal muscle. Analysis of inflammatory markers, gene expression, and metabolic intermediates linked disease-related disruptions in muscle inflammatory signaling, remodeling, and metabolic programming to physical inactivity and disability. Thus, skeletal muscle dysfunction might contribute to a viscous cycle of RA disease activity, physical inactivity, and disability. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 14% |
| Student > Ph. D. Student | 12 | 11% |
| Researcher | 11 | 10% |
| Student > Bachelor | 10 | 9% |
| Professor | 9 | 8% |
| Other | 27 | 25% |
| Unknown | 26 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 23% |
| Biochemistry, Genetics and Molecular Biology | 18 | 16% |
| Sports and Recreations | 11 | 10% |
| Agricultural and Biological Sciences | 5 | 5% |
| Engineering | 5 | 5% |
| Other | 14 | 13% |
| Unknown | 32 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2017.
All research outputs
#20,660,571
of 25,377,790 outputs
Outputs from Arthritis Research & Therapy
#2,907
of 3,380 outputs
Outputs of similar age
#320,809
of 422,539 outputs
Outputs of similar age from Arthritis Research & Therapy
#42
of 49 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,539 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.