Title |
The evolving concept of liver cancer stem cells
|
---|---|
Published in |
Molecular Cancer, January 2017
|
DOI | 10.1186/s12943-016-0572-9 |
Pubmed ID | |
Authors |
Kouki Nio, Taro Yamashita, Shuichi Kaneko |
Abstract |
Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to the presence of cancer stem cells (CSCs). In the past few decades, CSCs have been identified and characterized in many tumors including liver cancer. Accumulated evidence has revealed many aspects of the biological behavior of liver CSCs and the mechanism of their regulation. Based on these findings, a number of studies have investigated eradication of liver CSCs. This review focuses on the recent advances in our understanding of the biology of liver CSCs and the development of strategies for their treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 124 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 17% |
Student > Master | 12 | 10% |
Researcher | 11 | 9% |
Student > Doctoral Student | 10 | 8% |
Student > Bachelor | 9 | 7% |
Other | 9 | 7% |
Unknown | 52 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 28 | 23% |
Agricultural and Biological Sciences | 11 | 9% |
Medicine and Dentistry | 10 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Immunology and Microbiology | 2 | 2% |
Other | 11 | 9% |
Unknown | 58 | 47% |