Title |
Macrophages and angiogenesis in rheumatic diseases
|
---|---|
Published in |
Vascular Cell, June 2013
|
DOI | 10.1186/2045-824x-5-11 |
Pubmed ID | |
Authors |
Nicola Maruotti, Tiziana Annese, Francesco Paolo Cantatore, Domenico Ribatti |
Abstract |
Angiogenesis plays a key role in several rheumatic diseases, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic sclerosis, systemic lupus erythematosus, and vasculitides. An imbalance between angiogenic inducers and inhibitors seems to be a critical factor in pathogenesis of these diseases. Macrophages promote angiogenesis during rheumatoid arthritis. In addition, macrophages can produce a variety of pro-angiogenic factors that have been associated with the angiogenic response occurring during other rheumatic diseases. Lastly, macrophages could be a target in the treatment of rheumatoid arthritis and other rheumatic diseases. Nevertheless, further studies are needed to better elucidate the exact role of macrophage in angiogenesis in these diseases. |
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Geographical breakdown
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United Kingdom | 2 | 3% |
Belgium | 1 | 1% |
Canada | 1 | 1% |
Unknown | 65 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 19% |
Student > Ph. D. Student | 10 | 14% |
Researcher | 9 | 13% |
Student > Bachelor | 5 | 7% |
Student > Doctoral Student | 4 | 6% |
Other | 16 | 23% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 17% |
Immunology and Microbiology | 10 | 14% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Agricultural and Biological Sciences | 9 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
Other | 8 | 12% |
Unknown | 15 | 22% |