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The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer’s disease

Overview of attention for article published in Acta Neuropathologica Communications, July 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

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1 blog
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2 X users

Citations

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19 Dimensions

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48 Mendeley
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Title
The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer’s disease
Published in
Acta Neuropathologica Communications, July 2013
DOI 10.1186/2051-5960-1-30
Pubmed ID
Authors

Rachel H Tan, Karen Pok, Stephanie Wong, Daniel Brooks, Glenda M Halliday, Jillian J Kril

Abstract

Early atrophy of the cingulate cortex is a feature of both behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), with degeneration of the anterior cingulate region increasingly recognized as a strong predictor of bvFTD. The total number of neurons in this region, rather than the density of neurons, is associated with mood disturbance in other dementias, although there are no data on the extent and magnitude of neuronal loss in patients with bvFTD. While the density of small populations of neurons in this region has been assessed, it is unlikely that the degree of atrophy of the cingulate cortex seen in bvFTD can be explained by the loss of these subpopulations. This suggests that there is more generalized degeneration of neurons in this region in bvFTD.The present study assesses total neuronal number, as well as characteristic pathologies, in the anterior and posterior cingulate cortices of pathologically confirmed bvFTD (N = 11) and AD (N = 9) patients compared with age-matched controls (N = 14). The bvFTD cohort comprised 5 cases with tau pathology (Pick's disease), and 6 with TDP-43 pathology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 15%
Student > Master 6 13%
Student > Postgraduate 5 10%
Student > Bachelor 4 8%
Researcher 4 8%
Other 4 8%
Unknown 18 38%
Readers by discipline Count As %
Neuroscience 9 19%
Psychology 5 10%
Medicine and Dentistry 4 8%
Agricultural and Biological Sciences 3 6%
Social Sciences 2 4%
Other 4 8%
Unknown 21 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2014.
All research outputs
#3,259,932
of 22,713,403 outputs
Outputs from Acta Neuropathologica Communications
#735
of 1,366 outputs
Outputs of similar age
#28,936
of 194,389 outputs
Outputs of similar age from Acta Neuropathologica Communications
#4
of 27 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,366 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,389 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.