Title |
D-isoascorbyl palmitate: lipase-catalyzed synthesis, structural characterization and process optimization using response surface methodology
|
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Published in |
BMC Chemistry, July 2013
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DOI | 10.1186/1752-153x-7-114 |
Pubmed ID | |
Authors |
Wen-Jing Sun, Hong-Xia Zhao, Feng-Jie Cui, Yun-Hong Li, Si-Lian Yu, Qiang Zhou, Jing-Ya Qian, Ying Dong |
Abstract |
Isoascorbic acid is a stereoisomer of L-ascorbic acid, and widely used as a food antioxidant. However, its highly hydrophilic behavior prevents its application in cosmetics or fats and oils-based foods. To overcome this problem, D-isoascorbyl palmitate was synthesized in the present study for improving the isoascorbic acid's oil solubility with an immobilized lipase in organic media. The structural information of synthesized product was clarified using LC-ESI-MS, FT-IR, 1H and 13C NMR analysis, and process parameters for high yield of D-isoascorbyl palmitate were optimized by using One-factor-at-a-time experiments and response surface methodology (RSM). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 33% |
Researcher | 7 | 23% |
Student > Master | 3 | 10% |
Professor | 2 | 7% |
Other | 2 | 7% |
Other | 3 | 10% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 8 | 27% |
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Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 4 | 13% |
Unknown | 8 | 27% |