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Experimental validation of contrast-enhanced SSFP cine CMR for quantification of myocardium at risk in acute myocardial infarction

Overview of attention for article published in Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd), January 2017
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Average Attention Score compared to outputs of the same age and source

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6 tweeters
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1 Facebook page

Citations

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22 Dimensions

Readers on

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30 Mendeley
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Title
Experimental validation of contrast-enhanced SSFP cine CMR for quantification of myocardium at risk in acute myocardial infarction
Published in
Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd), January 2017
DOI 10.1186/s12968-017-0325-y
Pubmed ID
Authors

David Nordlund, Mikael Kanski, Robert Jablonowski, Sasha Koul, David Erlinge, Marcus Carlsson, Henrik Engblom, Anthony H. Aletras, Håkan Arheden

Abstract

Accurate assessment of myocardium at risk (MaR) after acute myocardial infarction (AMI) is necessary when assessing myocardial salvage. Contrast-enhanced steady-state free precession (CE-SSFP) is a recently developed cardiovascular magnetic resonance (CMR) method for assessment of MaR up to 1 week after AMI. Our aim was to validate CE-SSFP for determination of MaR in an experimental porcine model using myocardial perfusion single-photon emission computed tomography (MPS) as a reference standard and to test the stability of MaR-quantification over time after injecting gadolinium-based contrast. Eleven pigs were subjected to either 35 or 40 min occlusion of the left anterior descending artery followed by six hours of reperfusion. A technetium-based perfusion tracer was administered intravenously ten minutes before reperfusion. In-vivo and ex-vivo CE-SSFP CMR was performed followed by ex-vivo MPS imaging. MaR was expressed as % of left ventricular mass (LVM). There was good agreement between MaR by ex-vivo CMR and MaR by MPS (bias: 1 ± 3% LVM, r (2) = 0.92, p < 0.001), between ex-vivo and in-vivo CMR (bias 0 ± 2% LVM, r (2) = 0.94, p < 0.001) and between in-vivo CMR and MPS (bias -2 ± 3% LVM, r (2) = 0.87, p < 0.001. No change in MaR was seen over the first 30 min after contrast injection (p = 0.95). Contrast-enhanced SSFP cine CMR can be used to measure MaR, both in vivo and ex vivo, in a porcine model with good accuracy and precision over the first 30 min after contrast injection. This offers the option to use the less complex ex-vivo imaging when determining myocardial salvage in experimental studies.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 27%
Researcher 6 20%
Student > Doctoral Student 2 7%
Student > Bachelor 1 3%
Professor 1 3%
Other 3 10%
Unknown 9 30%
Readers by discipline Count As %
Medicine and Dentistry 9 30%
Engineering 4 13%
Mathematics 2 7%
Social Sciences 1 3%
Nursing and Health Professions 1 3%
Other 2 7%
Unknown 11 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2017.
All research outputs
#5,116,033
of 17,026,329 outputs
Outputs from Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd)
#476
of 1,042 outputs
Outputs of similar age
#118,722
of 364,855 outputs
Outputs of similar age from Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd)
#18
of 27 outputs
Altmetric has tracked 17,026,329 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,042 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,855 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.