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Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes

Overview of attention for article published in BMC Genomics, July 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Citations

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Title
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes
Published in
BMC Genomics, July 2013
DOI 10.1186/1471-2164-14-462
Pubmed ID
Authors

Kathrin K Geyer, Iain W Chalmers, Neil MacKintosh, Julie E Hirst, Rory Geoghegan, Mathieu Badets, Peter M Brophy, Klaus Brehm, Karl F Hoffmann

Abstract

The phylum Platyhelminthes (flatworms) contains an important group of bilaterian organisms responsible for many debilitating and chronic infectious diseases of human and animal populations inhabiting the planet today. In addition to their biomedical and veterinary relevance, some platyhelminths are also frequently used models for understanding tissue regeneration and stem cell biology. Therefore, the molecular (genetic and epigenetic) characteristics that underlie trophic specialism, pathogenicity or developmental maturation are likely to be pivotal in our continued studies of this important metazoan group. Indeed, in contrast to earlier studies that failed to detect evidence of cytosine or adenine methylation in parasitic flatworm taxa, our laboratory has recently defined a critical role for cytosine methylation in Schistosoma mansoni oviposition, egg maturation and ovarian development. Thus, in order to identify whether this epigenetic modification features in other platyhelminth species or is a novelty of S. mansoni, we conducted a study simultaneously surveying for DNA methylation machinery components and DNA methylation marks throughout the phylum using both parasitic and non-parasitic representatives.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 2 2%
Japan 2 2%
United Kingdom 2 2%
Portugal 1 1%
Norway 1 1%
Canada 1 1%
Germany 1 1%
United States 1 1%
Unknown 86 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 24%
Researcher 16 16%
Student > Master 14 14%
Student > Doctoral Student 7 7%
Professor 6 6%
Other 20 21%
Unknown 11 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 48%
Biochemistry, Genetics and Molecular Biology 20 21%
Veterinary Science and Veterinary Medicine 5 5%
Engineering 2 2%
Earth and Planetary Sciences 2 2%
Other 7 7%
Unknown 14 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2018.
All research outputs
#972,429
of 15,799,426 outputs
Outputs from BMC Genomics
#255
of 8,818 outputs
Outputs of similar age
#10,858
of 158,260 outputs
Outputs of similar age from BMC Genomics
#1
of 2 outputs
Altmetric has tracked 15,799,426 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,818 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 158,260 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them