Title |
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes
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Published in |
BMC Genomics, July 2013
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DOI | 10.1186/1471-2164-14-462 |
Pubmed ID | |
Authors |
Kathrin K Geyer, Iain W Chalmers, Neil MacKintosh, Julie E Hirst, Rory Geoghegan, Mathieu Badets, Peter M Brophy, Klaus Brehm, Karl F Hoffmann |
Abstract |
The phylum Platyhelminthes (flatworms) contains an important group of bilaterian organisms responsible for many debilitating and chronic infectious diseases of human and animal populations inhabiting the planet today. In addition to their biomedical and veterinary relevance, some platyhelminths are also frequently used models for understanding tissue regeneration and stem cell biology. Therefore, the molecular (genetic and epigenetic) characteristics that underlie trophic specialism, pathogenicity or developmental maturation are likely to be pivotal in our continued studies of this important metazoan group. Indeed, in contrast to earlier studies that failed to detect evidence of cytosine or adenine methylation in parasitic flatworm taxa, our laboratory has recently defined a critical role for cytosine methylation in Schistosoma mansoni oviposition, egg maturation and ovarian development. Thus, in order to identify whether this epigenetic modification features in other platyhelminth species or is a novelty of S. mansoni, we conducted a study simultaneously surveying for DNA methylation machinery components and DNA methylation marks throughout the phylum using both parasitic and non-parasitic representatives. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 17% |
China | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 50% |
Members of the public | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
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Uruguay | 2 | 2% |
Japan | 2 | 2% |
Germany | 1 | <1% |
Norway | 1 | <1% |
United Kingdom | 1 | <1% |
Portugal | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 95 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 15% |
Student > Master | 14 | 13% |
Professor | 6 | 6% |
Student > Doctoral Student | 6 | 6% |
Other | 20 | 19% |
Unknown | 21 | 20% |
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Biochemistry, Genetics and Molecular Biology | 20 | 19% |
Veterinary Science and Veterinary Medicine | 5 | 5% |
Engineering | 3 | 3% |
Earth and Planetary Sciences | 2 | 2% |
Other | 6 | 6% |
Unknown | 23 | 22% |