Title |
A quantitative atlas of histone modification signatures from human cancer cells
|
---|---|
Published in |
Epigenetics & Chromatin, July 2013
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DOI | 10.1186/1756-8935-6-20 |
Pubmed ID | |
Authors |
Gary LeRoy, Peter A DiMaggio, Eric Y Chan, Barry M Zee, M Andres Blanco, Barbara Bryant, Ian Z Flaniken, Sherry Liu, Yibin Kang, Patrick Trojer, Benjamin A Garcia |
Abstract |
An integral component of cancer biology is the understanding of molecular properties uniquely distinguishing one cancer type from another. One class of such properties is histone post-translational modifications (PTMs). Many histone PTMs are linked to the same diverse nuclear functions implicated in cancer development, including transcriptional activation and epigenetic regulation, which are often indirectly assayed with standard genomic technologies. Thus, there is a need for a comprehensive and quantitative profiling of cancer lines focused on their chromatin modification states. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Netherlands | 2 | <1% |
Poland | 2 | <1% |
France | 1 | <1% |
Austria | 1 | <1% |
Brazil | 1 | <1% |
Israel | 1 | <1% |
Germany | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Other | 3 | 1% |
Unknown | 200 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 74 | 34% |
Researcher | 51 | 24% |
Student > Master | 20 | 9% |
Student > Bachelor | 12 | 6% |
Student > Doctoral Student | 7 | 3% |
Other | 26 | 12% |
Unknown | 27 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 87 | 40% |
Biochemistry, Genetics and Molecular Biology | 52 | 24% |
Medicine and Dentistry | 15 | 7% |
Chemistry | 11 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
Other | 18 | 8% |
Unknown | 29 | 13% |