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Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury

Overview of attention for article published in Critical Care, July 2013
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Title
Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury
Published in
Critical Care, July 2013
DOI 10.1186/cc12808
Pubmed ID
Authors

Khodor Issa, Antoine Kimmoun, Solène Collin, Frederique Ganster, Sophie Fremont-Orlowski, Pierre Asfar, Paul-Michel Mertes, Bruno Levy

Abstract

Haemorrhagic shock is associated with an inflammatory response consecutive to ischaemia-reperfusion (I/R) that leads to cardiovascular failure and organ injury. The role of and the timing of administration of hydrogen sulphide (H2S) remain uncertain. Vascular effects of H2S are mainly mediated through K+ATP-channel activation. Herein, we compared the effects of D,L-propargylglycine (PAG), an inhibitor of H2S production, as well as sodium hydrosulphide (NaHS), an H2S donor, on haemodynamics, vascular reactivity and cellular pathways in a rat model of I/R. We also compared the haemodynamic effects of NaHS administered before and 10 minutes after reperfusion.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 3%
Brazil 1 3%
Unknown 31 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 15%
Student > Bachelor 5 15%
Student > Doctoral Student 3 9%
Student > Ph. D. Student 3 9%
Other 2 6%
Other 5 15%
Unknown 10 30%
Readers by discipline Count As %
Medicine and Dentistry 14 42%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Nursing and Health Professions 1 3%
Social Sciences 1 3%
Other 3 9%
Unknown 11 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2013.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Critical Care
#5,970
of 6,554 outputs
Outputs of similar age
#157,099
of 206,386 outputs
Outputs of similar age from Critical Care
#76
of 100 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,386 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.