Title |
Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury
|
---|---|
Published in |
Critical Care, July 2013
|
DOI | 10.1186/cc12808 |
Pubmed ID | |
Authors |
Khodor Issa, Antoine Kimmoun, Solène Collin, Frederique Ganster, Sophie Fremont-Orlowski, Pierre Asfar, Paul-Michel Mertes, Bruno Levy |
Abstract |
Haemorrhagic shock is associated with an inflammatory response consecutive to ischaemia-reperfusion (I/R) that leads to cardiovascular failure and organ injury. The role of and the timing of administration of hydrogen sulphide (H2S) remain uncertain. Vascular effects of H2S are mainly mediated through K+ATP-channel activation. Herein, we compared the effects of D,L-propargylglycine (PAG), an inhibitor of H2S production, as well as sodium hydrosulphide (NaHS), an H2S donor, on haemodynamics, vascular reactivity and cellular pathways in a rat model of I/R. We also compared the haemodynamic effects of NaHS administered before and 10 minutes after reperfusion. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 31 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 15% |
Student > Bachelor | 5 | 15% |
Student > Doctoral Student | 3 | 9% |
Student > Ph. D. Student | 3 | 9% |
Other | 2 | 6% |
Other | 5 | 15% |
Unknown | 10 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 42% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Social Sciences | 1 | 3% |
Other | 3 | 9% |
Unknown | 11 | 33% |